Synopses & Reviews
During recent decades the somatic mutation theory for the causation of cancer has held sway. The influence of environmental factors in the aetiology of cancer has become a matter of debate between those who maintain that it is largely a degenerative phenomenon and other voices who increasingly support the hypothesis that environmental factors predominate. An examination of some aspects of this debate is the prime purpose of this book. The increasing incidence of cancer across many parts of the world, particularly in children, has happened over a very short period of time in evolutionary terms. One can infer that it is connected to changes in the environment and/or our lifestyles. A major counter-argument to this contention is that rising cancer incidence is mainly because the average life expectancy has increased.These pages contain a number of chapters from specialists in the field who consider, from a number of different perspectives, the currently available evidence that supports the environmental cancer aetiology hypothesis. This constitutes the first part of the book. In the second part of the book, an examination of the policy implications of accepting that the cancer epidemic may essentially be preventable is presented. This will pose some difficult problems for politicians and decision-makers, who will have to consider adopting policies that may damage the economy in the short term in order to reap health benefits which will only become apparent several decades in the future.
Synopsis
- Controversial topic because many of the proposed solutions or policies may damage the economy in the short term in order to reap health benefits which will only become apparent several decades in the future - Each chapter is written by experts in the field throughout the world
Table of Contents
- Preface and acknowledgements. List of contributors. List of figures. List of tables. List of boxes.
- Introduction: cancer and the environment - revisiting traditional views of involuntary exposure to carcinogens; P. Nicolopoulou-Stamati, M.A. Pitsos. Summary. 1. Introduction. 2. Cancer and the environment. 3. Competing theories of aetiological mechanisms in cancer. 4. Exposure to carcinogens in early life - a strong indication that environmental influences are important. 5. Goal of this book. 6. Conclusions. References.
- Incorporating the environmental context in the study of cancer: issues and implications; A. Novogradec, S. Harris Ali. Summary. 1. Introduction. 2. Evidence for the environmental basis of cancer. 3. Studying the cancer and environment relationship. 4. Implications of risk assessment for cancer policy and intervention. 5. Conclusions. References.
- Could the increase in cancer incidence be related to recent environmental changes? C.V. Howard, J.A. Newby. Summary 1. Introduction. 2. Cancer in pre-industrial society. 3. The increase in average life expectancy. 4. Cancer incidence vs. mortality rate. 5. Human epidemiological evidence that environmental factors are paramount in the aetiology of cancer. 6. Could chronic low dose exposure to carcinogens lead to cancer. 7. Changes in patterns of human development. 8. Temporal patterns of change. 9. Changes in the patterns of human exposure to ionising radiation. 10. Public perceptions. 11. Conclusions. Acknowledgements. References.
- The role of DNA damage and DNA-damaging environmental chemicals in carcinogenesis; K. Peltonen. Summary 1. Introduction. 2. Metabolism. 3. Chemical carcinogenesis. 4. Biomarkers of exposure. 5. Methods of detection. 6. Conclusions. Acknowledgements. References.
- Gene-environment interaction in environmental carcinogens; H. Autrup. Summary 1. Introduction. 2. Metabolism of chemical carcinogens. 3. Gen-gene interaction. 4. Defence against oxidative stress. 5. Conclusions. References.
- Health impact assessment of accidents with environmental carcinogens: a case study of the Belgian PCB/dioxin incident in 1999; L. Hens. Summary 1. Introduction. 2. Phenomenology of the Belgian PCB/dioxin incident in 1999. 3. Hazard identification. 4. Dose-response assessment. 5. Exposure assessment. 6. Risk assessment. 7. Conclusion. References.
- Anti-oxidants and chemopreventive agents as cancer enhancing agent: the other side of the coin; S.Z. Abdel-Rahman, M. Paolini, M.S. Legator. Summary. 1. Introduction. 2. Co-carcinogenic properties of &bgr;CT. 3. The co-carcinogenicity of &bgr;-carotene enhances the transformation potential of benzo[a]pyrene and cigarette smoke condensate. 4. Cruciferae vegetables, glucosinolates and chemoprevention. 5. Co-carcinogenic properties of glucoraphanin, the natural bioprecursor of sulforaphane. 6. Conclusions. Acknowledgements. References.
- Legislative proposals for reversing the cancer epidemic and controlling run-away industrial technologies; S.S. Epstein. Summary. 1. Losing the winnable war against cancer (Epstein, 1998). 2. The legislative proposals. 3. The precautionary principle: prohibition of new carcinogenic products and untested new technologies. 4. Reduction of toxics in use. 5. Right to know. 6. Transparent decision-making on cancer, other public health and environmental effects. 7. White collar crime. 8. Independent citizen health and safety agency. References.
- Re-evaluation of priorities in addressing the cancer issue: conclusions, strategies, prospects; P. Nicolopoulou-Stamati, C.V. Howard, B.A.J. Gaudet. Summary. 1. Introduction. 2. Scientific basis for cancer as an environmental disease. 3. Target groups. 4. Policy. 5. EU policy. 6. Conclusions. References.
- List of abbreviations. List of units. Index.