Much progress has been made in discovering and developing agents that have promise, or have already been successfully used, to treat precancerous conditions or inhibit carcinogenesis. In Cancer Chemoprevention, Volume 1: Promising Cancer Chemopreventive Agents, leading researchers in the discovery and development of chemopreventives comprehensively survey all aspects of these emerging therapeutics. For each agent, the authors review the relevant mechanisms of action, the criteria for populations benefiting from intervention, the safety and pharmacodynamics, clinical study design emphasizing the use of precancers, and early associated cellular and molecular biomarkers of carcinogenesis. The pharmacologic and/or mechanistic classes discussed range from antimutagens, antiinflammatories, and the nuclear receptor superfamily, to signal transduction modulators, antioxidants, vitamins, and minerals. The classes vary widely in terms of their stages of development as chemopreventives and include both extensively studied groups and those with recently identified potential based on such mechanistic data as protein kinase inhibition. Attention is also devoted to nutriceuticals (food-derived agents) because of their high promise for prevention in healthy populations. The overall focus is on molecular targets and mechanisms. A second volume, Strategies for Cancer Chemoprevention, describes the exciting methodologies that are accelerating progress in this field and discusses the state of clinical development of chemoprevention in the various human cancer target organs. Up-to-date and highly practical, Cancer Chemoprevention, Volumes 1 & 2, offer oncologists, pharmacologists, medicinal chemists, and toxicologists a comprehensive reference survey on the identification of promising cancer chemopreventive agents that will help stimulate further research and the development of novel approvable drugs.
"...a comprehensive review of seizures...a wealth of information." - British Journal of Anesthesiology "...a valuable addition to any library in a lboratory researching/developing oncology products..." - BTS Newsletter "...provides a comprehensive reference survey for basic researchers, pharmacologists and clinical oncologists...a must for everyone involved in chemoprevention research." - Annals of Oncology
A comprehensive reference survey on the identification and development of promising cancer chemopreventive agents that will help stimulate further novel research and new approvable drugs. For each agent, the authors review the relevant mechanisms of action, the criteria for populations benefiting from intervention, the safety and pharmacodynamics, clinical study design emphasizing the use of precancers, and early associated cellular and molecular biomarkers of carcinogenesis. The pharmacologic and/or mechanistic classes discussed range from antimutagens, antiinflammatories, and the nuclear receptor superfamily, to signal transduction modulators, antioxidants, vitamins, and minerals. The overall focus is on molecular targets and mechanisms. A second volume, Strategies in Chemoprevention, describes the exciting methodologies that will accelerate progress in this field and discusses the state of clinical development of chemoprevention in the various human cancer target organs.
Part I. Antimutagens
Inducers of Enzymes That Protect Against Carcinogens and Oxidants: Drug- and Food-Based Approaches with Dithiolethiones and Sulforaphane
Thomas W. Kensler and Paul Talalay
Chemoprevention by Isothiocyanates
Stephen S. Hecht
Antigenotoxic and Cancer Preventive Mechanisms of N-Acetyl-l-Cysteine
Silvio De Flora, Alberto Izzotti, Adriana Albini, Francesco D'Agostini, Maria Bagnasco, and Roumen Balansky
Modifiers of Cytochrome(s) P450
John DiGiovanni and Heather E. Kleiner
Part II. Antiinflammatories
Antiinflammatories and Chemoprevention: NSAIDs and Other Inhibitors of Arachidonic Acid Metabolism
Gary B. Gordon, Gary J. Kelloff, and Caroline C. Sigman
Cyclooxygenase-2 Inhibitors and Colorectal Cancer Prevention
Raymond N. DuBois
Lipoxygenases as Targets for Cancer Prevention
Susan M. Fischer and Russell D. Klein
Inducible Nitric Oxide Synthase as a Target for Chemoprevention
Lorne J. Hofseth, Tomohiro Sawa, S. Perwez Hussain, and Curtis C. Harris
Chemoprevention of Cancer of the Respiratory Tract by Agents Delivered by Aerosol: Applications to Glucocorticoids and 5-Fluorouracil
Timothy S. Wiedmann and Lee W. Wattenberg
Chemoprevention of Cancer by Curcumin
Bandaru S. Reddy and Chinthalapally V. Rao
Prostacyclin and Lung Cancer Chemoprevention
Robert L. Keith, York E. Miller, Paul A. Bunn Jr., Patrick Nana-Sinkam, Raphael A. Nemenoff, and Mark W. Geraci
Part III. Nuclear Receptor Superfamily
Nuclear Receptor Superfamily: Targets for Chemoprevention
Julia A. Lawrence and Kapil Dhingra
A. Antiandrogens
Prostate Cancer Chemoprevention: 5a-Reductase Inhibitors
Jennifer E. Drisko and Siu-Long Yao
Searching for SARA: The Role of Selective Androgen-Receptor Antagonists in Prostate Cancer
Mark S. Chapman, William Y. Chang, Andrés Negro-Vilar, and Jeffrey N. Miner
B. Antiestrogens
Aromatase Inhibitors as Chemopreventives of Breast Cancer
Mitchell Dowsett and Judy E. Garber
Breast Cancer Chemoprevention by Selective Estrogen Receptor Modulators
Carolyn L. Smith
C. Natural Vitamin D and Synthetic Analogs
Chemopreventive Efficacy of Natural Vitamin D and Synthetic Analogs
Kathryn Z. Guyton, Thomas W. Kensler, and Gary H. Posner
D. Retinoids
The Retinoids and Cancer Chemoprevention
Sutisak Kitareewan, Ian Pitha-Rowe, Yan Ma, Sarah J. Freemantle, and Ethan Dmitrovsky
E. Dehydroepiandrosterone and Structural Analogs
Biologic and Therapeutic Effects of Dehydroepiandrosterone and Structural Analogs
Arthur G. Schwartz and Laura L. Pashko
Part IV. Signal Transduction Modulators
ras Oncogene Inhibitors
Nancy E. Kohl
The Potential of EGFR-Targeted Agents in Cancer Prevention
Steven D. Averbuch and Fadlo R. Khuri
Pharmacological Intervention with Multistep Oncogenesis: Potential Role for HSP90 Molecular Chaperone Inhibitors
Paul Workman
Therapeutic Strategies Targeting Polyamines
Debora L. Kramer and Eugene W. Gerner
The Role of Phytoestrogens as Cancer Prevention Agents
Stephen Barnes and Coral A. Lamartiniere
Cancer Chemopreventive Activity of Monoterpenes and Other Isoprenoids
Pamela L. Crowell and Michael N. Gould
Development of an Inhibitor of raf Kinase
Frank McCormick
Abnormalities in Cell Cycle Control in Human Cancer and Their Relevance to Chemoprevention
Alessandro Sgambato and I. Bernard Weinstein
Select Cyclic Nucleotide Phosphodiesterase Inhibitors in Colon Tumor Chemoprevention and Chemotherapy
Melissa K. Reeder, Rifat Pamakcu, I. Bernard Weinstein, Kirk Hoffman, and W. Joseph Thompson
Part V. Antioxidants, Vitamins, and Minerals
Chemoprevention by Fruit Phenolic Compounds
Gary D. Stoner and Bruce C. Casto
Tea Polyphenols as Cancer Chemopreventive Agents
Vaqar M. Adhami, Farrukh Afaq, Nihal Ahmad, Yukihiko Hara, and Hasan Mukhtar
Vitamin E as a Cancer Chemopreventive Agent
Han-Yao Huang, Sonja Berndt, and Kathy J. Helzlsouer
Vitamin C as a Cancer Chemopreventive Agent
Jane Higdon and Balz Frei
Carotenoids
Susan T. Mayne and Brenda Cartmel
Lycopene, a Dietary Cancer Chemopreventive Agent
Andreas I. Constantinou and Richard B. van Breemen
Not All Chemopreventive Selenium Compounds are Created Equal
Karam El-Bayoumy
Calcium
John A. Baron
Folate and Cancer Chemoprevention
Shumin M. Zhang and Walter C. Willett
Conjugated Linoleic Acid as a Tumor Preventive Agent
David Kritchevsky and Michael W. Pariza
Chemopreventive Effects of Omega-3 Fatty Acids
Joanne R. Lupton and Robert S. Chapkin
Part VI. Agents Targeting Biological Processes Important in Cancer
Tumor Angiogenesis as a Target for Early Intervention and Cancer Prevention
William W. Li
Proteasome Inhibitors in Cancer Therapy
Julian Adams
Modulation of DNA Methylation for the Treatment and Prevention of Cancer
David S. Schrump
Targeting Histone Deacetylase as a Strategy for Cancer Prevention
Ho Jung Oh, Eun Joo Chung, Sunmin Lee, Andrea Loaiza-Perez, Edward A. Sausville, and Jane B. Trepel
Index