Synopses & Reviews
The volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. The cardiovascular and respiratory systems are tightly coupled, as their primary function is to supply oxygen to and remove carbon dioxide from the body's cells. Because physiological conduits have deformable and reactive walls, macroscopic flow behavior and prediction must be coupled to nano- and microscopic events in a corrector scheme of regulated mechanisms. Therefore, investigation of flows of blood and air in physiological conduits requires an understanding of the biology, chemistry, and physics of these systems together with the mathematical tools to describe their functioning.
Circulatory and Ventilatory Systems focuses on cellular events that allow adaptation to environmental conditions, including cell proliferation and growth, migration, and death. Circadian cycles that drive rhythmic gene transcription are also covered.
Volume I of Circulatory and Ventilatory Systems focuses on cell structure and function (Part A) as well as cellular events that allow adaptation to environmental conditions (Part B).
Table of Contents
Chapters 1 and -2 gives a survey of cell types involved in the vasculature and respiratory tract, respectively.
Chapter 3 presents cells that belongs to the nervous and endocrine systems that are responsible for remote control.
Chapter 4 describes the cell with its major components.
Chapter 5 summarizes the knowledge acquired in protein synthesis, as most of signaling mediators are proteins.
Chapter 6 to 8 present certains aspects of cell fate and behavior. The cell division cycle and cell growth are treated in Chap. 6, involved growth factors are given in Chap. 7, and Chap. 8 and 9 are devoted to cell decision between survival and death on the one hand and circadian cycle on the other.
Chapter 10 focuses on cell cytoskeleton that is involved in cellular transport, cell division, cell adhesion and migration, and, last but not least, in cell adaptation to mechanical stresses.
Chapter 11 deals with the cell membrane and its relation to the cell environment. The extracellular matrix is a necessary medium for cell fate and tissue formation and remodeling due to applied mechanical stresses.
Chapter 12 deals with molecular transport in the cell in interaction with its environment.
Chapter 13 describes cell migration for tissue adaptation and repair.
Chapter 14 focuses on mucus layer that lies over a periciliary fluid in large airways as well as mediumsized and small brochi, whereas
Chapter 15 deals with airway-lining surfactant in pulmonary acinus.