Synopses & Reviews
Cellular Responses to Stress
brings together a group of scientists who work on different but interrelated aspects of cellular stress responses. The book provides state-of-the-art information on the wide spectrum of ways in which cells can respond to different forms of stress induced by chemicals, oxidants, and DNA-damaging agents. Mechanisms are described that involve altered uptake and efflux of chemical agents, intracellular detoxification, and DNA damage responses. Many of these changes trigger a cascade of reactions mediated by stress-activated signaling pathways, which have the capacity to determine whether a cell will survive or die. The spectrum of topics covered in this book aims to provide a broad overview of our current knowledge of the different forms of adaptive response systems.
It is hoped that this text will stimulate further research to establish the relative cellular role of specific response pathways and will enable us to gain a deeper understanding of the mechanisms that allow cells to live or die. This book will be valued by university researchers at all levels, industrial scientists in the pharmaceutical and biotechnology industries, and clinical researchers.
Originally published in 1999.
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Table of Contents
1 Signal transduction by the c-Jun N-terminal kinase By R.J. Davis 1
2 Roles of the AMP-activated/SNF1 protein kinase family in the response to cellular stress By D.G. Hardie 13
3 Making the connection: coupling of stress-activated ERY,/MAPK (extracellular-signal-regulated kinase/mitogen-activated protein kinase) core signalling modules to extracellular stimuli and biological responses By J.M. Kyriakis 29
4 Stress-activated MAP kinase (mitogen-activated protein kinase) pathways of budding and fission yeasts By J.B.A. Millar 49
5 Protein kinase cascades in intracellular signalling by interleukin-1 and tumour necrosis factor By J. Saklatvala, J. Dean and A. Finch 63
6 Regulation of actin dynamics by stress-activated protein kinase 2 (SAPK2) -dependent phosphorylation of heat-shock protein of 27 kDa (Hsp27) By J. Landry and J. Huot 79
7 DNA-dependent protein kinase and related proteins By G.C.M. Smith, N. Divecha, N.D. Lakin and S.P. Jackson 91
8 Stress-induced activation of the heat-shock response: cell and molecular biology of heat-shock factors By J.J. Cotto and R.I. Morimoto 105
9 Transcriptional regulation via redox-sensitive iron-sulphur centres in an oxidative stress response By B. Demple. E. Hidalgo and H. Ding 119
10 Adaptive responses to environmental chemicals By C.R. Wolf, G. Smith, A.G. Smith, K. Brown and C.J. Henderson 129
11 Cellular response to cancer chernopreventive agents: contribution of the antioxidant responsive element to the adaptive response to oxidative and chemical stress By J.D. Hayes, E.M. Ellis, G.E. Neal, D.J. Harrison and M.M. Manson 141
Subject index 169