Synopses & Reviews
Pharmaceutical and fine chemical products are typically synthesised batchwise which is an anomaly since batch processes have a series of practical and economical disadvantages. On the contrary, flow continuous processes present a series of advantages leading to new ways to synthesise chemical products. Flow processes - * enable control reaction parameters more precisely (temperature, residence time, amount of reagents and solvent etc.), leading to better reproducibility, safer and more reliable processes * can be performed more advantageously using immobilized reagents or catalysts * improve the selectivity and productivity of the process and possibly even the stability of the catalyst * offer opportunities for heat exchange and energy conservation as well as an easy separation and recycling of the reactants and products by adequate process design * achieve multistep syntheses by assembling a line of reactors with minimum or no purification in between two reaction steps * can be assured by facile automation * scale-up can be easily conducted by number-up With all the new research activity in manufacturing chemical products, this comprehensive book is very timely, as it summarises the latest trends in organic synthesis. It gives an insight into flow continuous processes, outlining the basic concepts and explaining the terminology of, and systems approach to, process design dealing with both homogeneous and heterogeneous catalysis and mini- or micro-reactors. The book contains case studies, extensive bibliographies and reference lists in each chapter to enable the reader to grasp the contents and to go on to more detailed texts on specific subjects if desired. The book is written by both organic chemists and engineers giving a multidisciplinary vision of the new tools and methodologies in this field. It is essential reading for organic chemists (in industry or academia) working alongside chemical engineers or who want to undertake chemical engineering projects. It will also be of interest for chemical engineers to see how basic engineering concepts are applied in modern organic chemistry.
Synopsis
With all the new research activity in manufacturing chemical products, this comprehensive book is very timely, as it summarises the latest trends in organic synthesis. It gives an insight into flow continuous processes, outlining the basic concepts and explaining the terminology of, and systems approach to, process design dealing with both homogeneous and heterogeneous catalysis and mini- or micro-reactors. The book contains case studies, extensive bibliographies and reference lists in each chapter to enable the reader to grasp the contents and to go on to more detailed texts on specific subjects if desired.
Synopsis
Summarises new trends in organic synthesis, based on flow continuous processes, mini- and micro-reactors, homogeneous and heterogeneous catalysts and reagents.
Synopsis
A new area is emerging in manufacturing chemical products and this comprehensive book summarises the latest trends in organic synthesis. It gives an insight into flow continuous processes, outlining the basic concepts and explaining the terminology of, and systems approach to, process design dealing with both homogeneous and heterogeneous catalysis and mini- or micro-reactors. The book is written by both organic chemists and engineers giving a multidisciplinary vision of the new tools and methodologies in this field. It is essential reading for organic chemists (in industry or academia) working alongside chemical engineers or who want to undertake chemical engineering projects. It will also be of interest for chemical engineers to see how basic engineering concepts are applied in modern organic chemistry.
About the Author
I obtained my Ph.D. degree in organic chemistry and materials science from the University Jaume I, Castellon (Spain). Over the past years as a result of my intensive research activity, I am co-author of 41 publications in per-reviewed International Chemistry Journals of the highest impact (such as Chem. Commun., Org. Lett., Adv. Synth. Catal., J. Org. Chem., Green Chem., Ind. and Eng. Chem. Res, etc...). In at least four of these publications, I appeared as a senior corresponding author, reflecting my research leadership. In addition, I have given 20 communications and 7 lectures in international conferences and Symposia. During my Ph.D. (1996-2001) I worked in the field of asymmetric synthesis and heterogeneous catalysis. I studied the role played by the support over the outcome of heterogeneous catalysed reaction. I have also worked in the synthesis of small-focused library of supported catalysts as a fast and easy tool for the development of more efficient asymmetric catalysts. I also developed methodologies based on FT-Raman as a simple tool for the fast monitoring of reactions on polymer and silica supported reagents and catalysts. After my Ph.D., I moved to work with one of the world leaders in supercritical fluid, Prof. M. Poliakoff, at the Clean Technology Group at Nottingham University. I was awarded with a very competitive individual Marie Curie Fellowship. During my stay in Nottingham, almost 4 years, I gained experience in a wide range of processes in supercritical water (SCW): reactor design, phase behaviour, oxidation reactions, and High Temperature High Pressure Spectroscopy, which were areas of knowledge completely new for me. Besides, I was involved in the training, mentoring and tutoring of 3 PhD students, 3 research visitors and two project students. I was also directly involved in join collaboration academy-industry (Invista Tech. Ltd.). I wish to point out the excellent productivity of this period generating 12 publications and 3 patens. Therefore, my post-doc is an excellent example of interdisciplinary training and transfer of knowledge. This is an ideal training required by both industry and academy to achieve a successful implementation of Green Chemistry. In 2004, I was awarded with the Ramon y Cajal contract (RyC) for research, which is a temporary position (5 years) within the Spanish research system. The applicants to this position are selected by an external committee in terms of their scientific excellence demonstrated until the moment of the application. The rate for a successful answer is only about 10%. Then, I showed exceptional scientific potential to my colleagues before my career really started to yield the most fruitful results. The RyC contract does not allow a complete independence, therefore I have been working with a highly reputed full professors in Organic Chemistry (S.V Luis and M.I. Burguete at University Jaume I). However, I was allowed to keep some intellectual independence, developing my own ideas while co-advising some PhD students. Since September 2004 I has initiated a highly innovative research integrating the so-called enabling techniques (catalysis, solid-phased assisted synthesis, continuous flow processes, microreactors, biocatalysis, neoteric solvents (ILs SCFs), etc). The combination of two or more of these techniques leading to truly new synthetic improved technology platforms. This is an emerging field newly created to develop novel chemical processes that would be both efficient from an industrial and economical point of view being more environmentally friendly. Our research will help to address the challenge of new ways to produce Fine Chemicals by using an innovative approach, which cuts across traditional disciplinary boundaries. Along my training, I have proved my ability to overcome the traditional interdisciplinary boundaries between the different areas of the knowledge. This multidisciplinary training has allowed to gain a unique combination of expertise and skills on Analytical Chemistry (spectroscopy), Organic Chemistry (Synthesis of chiral ligands, biosynthesis, asymmetric and non-asymmetric reactions), Material Science (Polymer Science and Heterogeneous Catalysis), Physical Chemistry (phase equilibrium, thermodynamics related to SCFs systems), and Engineering (design of reactors, microreactores) all of them required to obtain desired fruits. In overall, my experience, open mind and enthusiasm make me an ideal researcher to respond to the new challenges.
Table of Contents
Chapter 1: Engineering Factors for Efficient Flow Processes in Chemical Industries; Chapter 2: Flow Processes Using Polymer-supported Reagents, Scavengers and Catalysts; Chapter 3: Zeolites and related Materials for Developing Continuous Flow Systems; Chapter 4: Microfluidic Devices for Organic Processes; Chapter 5: Flow Processes in non-Conventional Media;