Synopses & Reviews
Since pharmacokinetics can greatly affect how different patients respond to the same drug, both students and physicians need a basic clinical understanding of this vital area. The Third Edition of Clinical Pharmacokinetics provides a practical perspective, with these added features considerations of both stereochemistry and the increasing number of polypeptide and protein drugs being developed; the range and number of problems at the end of each chapter has been expanded; a second color added to make the text more user friendly; important equations highlighted by shading.
Compatibility:
BlackBerry® OS 4.1 or Higher / iPhone/iPod Touch 2.0 or Higher /Palm OS 3.5 or higher / Palm Pre Classic / Symbian S60, 3rd edition (Nokia) / Windows Mobile™ Pocket PC (all versions) / Windows Mobile Smartphone / Windows 98SE/2000/ME/XP/Vista/Tablet PC
Review
-- "This textbook covers a tremendous range of topics important in pharmacokinetics and pharmacodynamics. No other textbook does this as effectively as the Rowland and Tozer text."
Review
-- "I believe this book is the best written text for bridging the gap between basic PK and clinical PK."
Synopsis
Since pharmacokinetics can greatly affect how different patients respond to the same drug, both students and physicians need a basic clinical understanding of this vital area. The Third Edition of Clinical Pharmacokinetics provides a practical perspective, with these added features considerations of both stereochemistry and the increasing number of polypeptide and protein drugs being developed; the range and number of problems at the end of each chapter has been expanded; a second color added to make the text more user friendly; important equations highlighted by shading.
Compatibility:
BlackBerry® OS 4.1 or Higher / iPhone/iPod Touch 2.0 or Higher /Palm OS 3.5 or higher / Palm Pre Classic / Symbian S60, 3rd edition (Nokia) / Windows Mobile™ Pocket PC (all versions) / Windows Mobile Smartphone / Windows 98SE/2000/ME/XP/Vista/Tablet PC
Synopsis
Formerly Clinical Pharmacokinetics: Concepts and Applications, this fully updated Fourth Edition has been retitled Clinical Pharmacokinetics and Pharmacodynamics: Concepts and Applications to reflect the increasing body of knowledge linking the two concepts that explain the relationship between drug administration and drug response. This revised edition also reflects the explosion in our understanding at the molecular and mechanistic levels of all the processes controlling the pharmacokinetics of drugs. The text is authored by two leading international experts on the clinical aspects of pharmacokinetics/pharmacodynamics and is widely considered one of the authoritative texts on the subject.
A companion website includes the full text online, plus interactive simulations for student practice using different pharmacokinetic/pharmacodynamic models and parameters.
Table of Contents
Preface
Definition of Symbols
Non-Proprietary and Brand Names of Drugs in Text and Illustrations
I. Basic Considerations
- 1. Therapeutic Relevance
- 2. Fundamental Concepts and Terminology
II. Exposure and Response after a Single Dose
- 3. Kinetics Following an Intravenous Bolus Dose
- 4. Membranes and Distribution
- 5. Elimination
- 6. Kinetics Following an Extravascular Dose
- 7. Absorption
- 8. Response Following a Single Dose
III. Therapeutic Regimens
- 9. Therapeutic Window
- 10. Constant-Rate Input
- 11. Multiple Dose Regimens
IV. Individualization
- 12.Variability
- 13.Genetics
- 14. Age, Weight, and Gender
- 15. Disease
- 16. Nonlinearities
- 17. Drug Interactions
- 18. Initiating and Managing Therapy
V. Supplemental Topics
- 19. Distribution Kinetics
- 20. Metabolites and Drug Response
- 21. New! Protein Drugs
- 22. New! Prediction and Refinement of Human Kinetics from In Vitro, Preclinical, and Early Clinical Data
Appendices
A. Assessment of AUC
B. Ionization and the pH Partition Hypothesis
C. Distribution of Drugs Extensively Bound to Plasma Proteins
D. Plasma-to-Blood Concentration Ratio
E. Well-stirred Model of Hepatic Clearance
F. Absorption Kinetics
G. Wagner-Nelson Method
H. Mean Residence Time
I. Amount of Drug in Body on Accumulation to Plateau
J. Answers to Study Problems