Synopses & Reviews
In complex macromolecules, minor modifications can generate major changes, due to self-assembling capacities of macromolecular or supramolecular networks. The authors highlight how the multifunctionality of several materials can be achieved and valorized for pharmaceutical and biopharmaceutical applications. Opening chapters cover the concept of self-assembling, starch and derivatives as pharmaceutical excipients and chitosan and derivatives as biomaterials and as pharmaceutical excipients. Following chapters discuss polyelectrolyte complexes as excipients for oral administration; natural semi-synthetic and synthetic materials, protein-protein associative interactions and their involvement in bioformulations; self-assembling materials, implants and xenografts; and provide conclusions and perspectives.
Editors Mateescu, Ispas-Szabo, and Assaad present this compilation ondrug delivery methods with a focus on systems mediated by self-assembly phenomena. The first chapter discusses the molecularinteractions involved in self-assembly. The ensuing chapters discuss specific delivery systems: the intrinsic advantages and structuraland chemical modifications of starches as pharmaceutical excipients, simple chitosan derivatives, chitosan polyelectrolyte complexesincluding various polysaccharides, natural polysaccharides, synthetic polymers, and natural-synthetic hybrids, and the chemistryof proteins relevant to their use either as excipients or drugs to be delivered.Annotation ©2015 Ringgold, Inc., Portland, OR (protoview.com)
About the Author
Mircea Alexandru Mateescu is Professor of Biochemistry at the Universite du Quebec a Montreal, Canada and a scientist with expertise in drug delivery systems and biochemical pharmacology. He is the inventor of several novel biomaterials with particular characteristics related to supramolecular self-assembling phenomena and a promoter of new technologies in pharmaceutical formulations.
Pompilia Ispas-Szabo is Adjunct Professor at the Universite du Quebec a Montreal, Canada. Her expertise relates to material science, formulation and characterization of drug delivery systems.
Elias Assaad is Research Associate at the Universite du Quebec a Montreal, Canada and has extensive experience in pharmaceutical research, particularly in the design of polymeric excipients for controlled drug delivery and in the conception of polyelectrolyte complexes.
Table of Contents
The concept of self-assembling; Starch and derivatives as pharmaceutical excipients; Chitosan and derivatives as biomaterials and as pharmaceutical excipients; Polyelectrolyte complexes as excipients for oral administration; Natural semi-synthetic and synthetic materials; Protein-protein associative interactions and their involvement in bioformulations; Self-assembling materials, implants and xenografts; Conclusions and perspectives