Synopses & Reviews
Synopsis
This text thoroughly reviews the latest findings and concepts on the vascular biology of diabetes mellitus, the clinical vascular manifestations of diabetes, and the therapeutic options available for diabetic patients with vascular disease. The first section provides an in-depth understanding of fundamental principles and recent discoveries regarding diabetes mellitus and vascular biology. The second, clinically oriented section includes chapters on the economic implications of diabetes mellitus, risk profiling patients with diabetes, optimizing adjunctive therapies, and treatment strategies for diabetic patients with coronary and peripheral artery disease. Summaries of important clinical trials are included to provide an evidence-based approach to treatment.
Table of Contents
Part I Vascular Biology
- Structure and Function of the Vessel Wall, 3
Mario B. Marrero and David M. Stern
- Antioxidants, Oxidative Stress, and Inflammation in Diabetes, 19
Sridevi Devaraj, Sonia Vega-López, and Ishwarlal Jialal
- Role of Protein Kinase C Isoforms in Diabetic Vascular Dysfunction, 37
Zhiheng He, Ronald C.W. Ma, and George L. King
- Aldose Reductase and Vascular Stress, 55
Ravichandran Ramasamy and Peter J Oates
- Peroxisome Proliferator-Activated Receptors and Diabetic Vasculature, 75
Peter J. Little, Duncan J. Topliss, Sunder Mudalier, and Ronald E. Law
- Receptor-Dependent Vascular Stress in Diabetes, 93
Ann Marie Schmidt, Barry I. Hudson, Shi-Fang Yan, and David M. Stern
- Genetic Determinants of Late Diabetic Complications, 111
Alessandro Doria, James H. Warram, and Andrzej S. Krolewski
- Diabetic Retinopathy and Vascular Endothelial Growth Factor, 133
Hans-Peter Hammes and Georg Breier
Part II Clinical Topics
- Epidemiology of Diabetes Mellitus and Cardiovascular Disease, 153
Sunil V. Rao and Darren K. McGuire
- Economic Implications of Diabetes Mellitus, 179
John D. Nachtigal and Cathryn A. Carroll
- Obesity, 199
Mark W. Conard and Walker S. Carlos Poston
- Diabetes Treatment, 219
William L. Isley
- Endothelial Dysfunction, 239
Joshua A. Beckman
- Platelet Dysfunction, 251
Robert Kelly and Steven R. Steinhubl
- Diabetes, Impaired Fibrinolysis, and Thrombosis, 269
Peter J. Grant and Lucinda K.M. Summers
- Restenosis, 293
David S. Lee and Marc S. Penn
- The Renin-Angiotensin System, Nephropathy, and Hypertension, 315
Roberto Trevisan and Giancarlo Viberti
- Lipoprotein Abnormalities, 337
William L. Isley and William S. Harris
- Diabetes Mellitus and Ischemic Heart Disease, 355
Benjamin H. Trichon and Matthew T. Roe
- Diabetes and Coronary Revascularization, 379
Deepak P. Vivekananthan and Deepak L. Bhatt
- Diabetes and Peripheral Artery Disease, 403
Roberto A. Corpus Appendix A. Adjunctive Pharmacology of Diabetes: Chain of Evidence, 423
Maureen E. Knell, Jared T. Lurk, and Jennifer M. Roth
Appendix B. Synopsis of Major Cardiovascular Trials Involving Diabetic Patients, 469
Avinash Khanna
Subject Index, 487