Synopses & Reviews
In this second edition of his popular and widely acclaimed book, Lewis Braverman and a panel of international authorities have thoroughly updated and revised the first edition with fresh perspectives, many new authors, and the latest scientific and clinical developments in thyroid disease. New to this edition are the clinical relevance of the sodium/iodide symporter (NIS), broad coverage of autoimmune thyroid disease, and expanded coverage of thyroid cancer, including recombinant human TSH. Other chapters discuss such important topics as thyroid dysfunction during pregnancy and postpartum, thyroid disease in children and the elderly, the evaluation and management of nodular goiter, the worldwide problem of iodine deficiency and its eradication, and environmental goitrogens. Authoritative and up-to-date, Diseases of the Thyroid, Second Edition, provides internists, family physicians, obstetricians and gynecologists, and endocrinologists alike with a highly readable guide not only to understanding thyroid disorders, but also to their optimal clinical management.
Review
"...contains many excellent, up-to-date, informative, and clinically valuable chapters...very readable. .." -Trends in Endocrinology and Metabolism "...a good book, of interest to all trainee endocrinologists and certainly of use as a vade mecum for established physicians with more than a passing interest in thyroid disease..." -New England Journal of Medicine "...integrates state-of-the-art science with sound clinical advice...essential reading for the general internist, but even the most experienced endocrinologists will find something new." -Netherlands Journal of Medicine "...an especially valuable reference for clinicians...recommend[ed]...for the personal library of any physician caring for patients with thyroid disorders." -Doody's Health Sciences Book Review Journal "This book would be an excellent purchase for any medical practitioner or health facility that treats people suffering from thyroid disease. It is concise, easy to use, and current. It is highly recommended as a resource for graduate level library collections supporting health or medical studies." - E-Streams "The chapters in this text are well organized and well written, and this book should be on the shelf as a reference text for those physicians treating and managing diseases of the thyroid." - Clinical Chemistry "This book would be an excellent purchase for any medical practitioner or health facility that treats people suffering from thyroid disease. It is concise, easy to use, and current. It is highly recommended as a resource for graduate level library collections supporting health or medical studies." -E-STREAMS "It would be a welcome addition to the library of an endocrinologist who wishes to be updated, in a user-friendly way, on the latest research advances in thyroidology." -TRENDS in Endocrinology and Metabolism
Synopsis
In the past five years, so much additional progress has been made in ourunderstanding of both the basic and c1inical aspects of a wide variety of thyroid disorders that a second edition of Diseases of the Thyroid was considered a necessary addition to the Contem- porary Endocrinology series. Fresh perspectives also seemed warranted, so we recruited new authors for many of the chapters and believe that this edition will provide the reader with further insights into the pathophysiology and c1inical presentation and treatment of thyroid disease. It inc1udes topics ranging from neonatal thyroid screening, thyroid dysfunction during infancy and childhood, peripartum thyroid disorders, thyroid disease in the elderly, and the c1inical relevance of the sodiurnliodide symporter (NIS) to the pathogenesis and treatment of nodular goiter, thyroid cancer, thyrotoxicosis, and hypothyroidism. The worldwide problem of iodine deficiency and its eradication is also discussed, along with environmental goitrogens and iodine-induced thyroid disease. I am indebted to all the contributors for their cooperation and expertise in providing their chapters in an extremely timely fashion, to Mr. Thomas Moore and Mr. Craig Adams from Humana Press for their expert assistance, and to Ms. Christine Archung for providing superb administrative assistance. Lewis E. Braverman, MD v CONTENTS Preface . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . v Contributors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ix Molecular Mechanisms of Nuclear Thyroid Hormone Action William W. Chin and Paul M. Yen . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 2 Nongenomic Actions of Thyroid Hormone Paul 1. Davis and F aith B. Davis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19 3 Thyroid Testing: A Clinical Approach Laurie A. Kane and Hossein Gharib . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Synopsis
This extensively revised and updated edition of a popular and widely acclaimed work presents the latest scientific and clinical developments in thyroid disease. New topics include the clinical relevance of the sodium/iodide symporter (NIS), broad coverage of autoimmune thyroid disease, and expanded coverage of thyroid cancer, including recombinant human TSH. Other chapters discuss thyroid dysfunction during pregnancy and postpartum, thyroid disease in children and the elderly, and the evaluation and management of nodular goiter. Diseases of the Thyroid, 2nd Edition, provides internists and family physicians, obstetricians and gynecologists, and endocrinologists alike with a highly readable guide to thyroid disorders and their clinical management.
Table of Contents
Molecular Mechanisms of Nuclear Thyroid Hormone Action William W. Chin and Paul M. Yen Nongenomic Actions of Thyroid Hormone Paul J. Davis and Faith B. Davis Thyroid Testing: A Clinical Approach Laurie A. Kane and Hossein Gharib Neonatal Screening for Thyroid Disease Marvin L. Mitchell and Cecilia A. Larson Thyroid Disease in Infancy, Childhood, and Adolescence Rosalind S. Brown Thyroid Disease in Older Persons Clark T. Sawin Autoimmune Thyroid Diseases Stefano Mariotti and Giovanni Pinna Problems in the Management of Hypothyroidism Paul W. Ladenson Management of the Various Causes of Thyrotoxicosis Douglas S. Ross Resistance to Thyroid Hormone Joshua D. Safer Evaluation and Management of the Euthyroid Nodular and Diffuse Goiter Peter A. Singer Radiation and Thyroid Cancer: Lessons from a Half Century of Study Arthur B. Schneider and Elaine Ron Management of Thyroid Cancer Stephanie L. Lee Thyroid Dysfunction During Pregnancy and After Delivery John H. Lazarus Goitrogens in the Environment Arnold Engel and Steven H. Lamm (based on Eduardo Gaitan) Iodine Deficiency and Its Elimination by Iodine Supplementation John T. Dunn Iodine-Induced Thyroid Disease Wilmar M. Wiersinga and Lewis E. Braverman Clinical Relevance of the Thyroid Sodium/Iodide Symporter Peter H. K. Eng and Su-Chin Ho Index