Synopses & Reviews
Following a brief introduction to drug toxicity as systemic effects that may occur with overdosage of a medication, accumulation of the drug in the body over time, or the inability of a patient's body to eliminate the drug, international scientists present recent research trends in this field. The first of eight chapters examines the pharmaceutical industry's use of new methods, under regulatory pressure, to detect drug toxicity earlier in the development and clinical trial process. Contributors treat toxicity issues relating to specific classes of drugs (e.g., antipsychotics, topical corticosteroids, COX-2 inhibitors); and the perplexing question of why the amino acid D-Serine is nephrotoxic in some experimental animals but not others. The editor's credentials are not stated.