Synopses & Reviews
The design and development of drugs and new pharmaceutical formulations require a full characterization of the chemical and physicochemical events occurring at the single active ingredient or excipients, as well as their reciprocal interaction. Thermal analysis techniques, such as the Differential Scanning Calorimetry (DSC), are among the most widely used methods to obtain this information. DSC is where the thermotropic behavior of a single substance or mixtures is analyzed as a function of a controlled temperature program.
The editor and contributors are scientists renowned for their work in the field of DSC applications to drug development and delivery, and especially in drug-biomembrane interaction studies. They combine insights from biochemistry and physiology with those from structural biology, nanotechnology and bio-thermodynamics, to obtain a complete depiction of cell membranes and their functions.
-Summarizes and updates the recent development of drug-biomembrane models interaction studies, particularly, in using calorimetry and DSC techniques, in a unique handbook/textbook style
-Consists of a combination of scientific updates within the field, and practical guidance for researchers or students who would like to reproduce or develop these kinds of studies -Updates significantly the research published or patented in this field, and provides an insight to the potential of further investigations
About the Author
Rosario Pignatello is Professor of Pharmaceutical Technology and Legislation at the University of Catania, Italy. His research activity in the area of innovative pharmaceutical technology in particular focuses on: preparation, physico-chemical characterization and biological evaluation of polymer micro- and nanoparticles as modified drug delivery systems and synthesis and technological investigation on chemically engineered polymers for drug delivery.
Table of Contents
Biological membranes and their role in physio- pathological conditions; Biomembrane models; Analytical methods for studying drug-biomembrane interactions; Differential scanning calorimetry (DSC): Theoretical fundamentals; DSC: History, instruments and devices; DSC in drug-biomembrane interaction studies; DSC applications: Macromolecules; DSC applications: Nucleic acids and membrane interactions; Non- steroidal anti- infl ammatory drugs; Antimicrobial agents; Drug delivery systems: Drug nanocarriers; Appendix 1: General experimental set-up of liposomal systems for DSC; Appendix 2: Journals