Synopses & Reviews
In this classic, originally published 25 years ago and now reprinted with a new Afterword by the author on how he came to write the book, Judson tells the story of the birth and early development of molecular biology, in the US, the UK and France. In particular, the fascinating account of the remarkable golden period from the revelation of the double helix structure of DNA through to cracking the genetic code and solving the basic problems of how genes are regulated, is told largely in the words of the main players in the unfolding drama, all of whom were interviewed extensively by Judson in preparing this acclaimed volume. As well as the new Afterword that appears here for the first time, the current edition contains the material added by the author to the earlier "Expanded Edition" (CSHL Press 1996) on some of the principal figures involved, particularly Rosalind Franklin, together with the Afterword added at that time which sketches the further development of molecular biology into the era of recombinant DNA.
Unavailable in the U.S. for many years, Horace Judson's remarkable lay history of molecular biology is now published in a new, expanded edition. The author has added new material on some of the principal figures involved, particularly Rosalind Franklin. Also included are a new Forward and an Afterword which sketches the further development of molecular biology into the era of recombinant DNA. No one active in current molecular genetics can fail to be informed and entertained by this extraordinary account of how it all began. Also highly recommended for students and interested lay people.
In this classic book, the distinguished science writer Horace Freeland Judson tells the story of the birth and early development of molecular biology in the US, the UK, and France. The fascinating story of the golden period from the revelation of the double helix of DNA to the cracking of the genetic code and first glimpses of gene regulation is told largely in the words of the main players, all of whom Judson interviewed extensively. The result is a book widely regarded as the best history of recent biological science yet published.
This commemorative edition, honoring the memory of the author who died in 2011, contains essays by his daughter Olivia Judson, Matthew Meselson, and Mark Ptashne and an obituary by Jason Pontin. It contains all the content added to previous editions, including essays on some of the principal historical figures involved, such as Rosalind Franklin, and a sketch of the further development of molecular biology in the era of recombinant DNA.
Includes bibliographical references (p. 639-693) and index.
Table of Contents
Foreword to the Commemorative Edition
Horace Freeland Judson Obituary
Growing Up with The Eighth Day: A Reminiscence
Preface to the Commemorative Edition
Horace Judson (1931-2011)
Preface to the expanded edition
Foreword to the expanded edition
Foreword to the first edition
Part I: DNA Function and Structure: The elucidation of the structure of deoxyribonucleic acid, the genetic material
1. "He was a very remarkable fellow. Even more odd then, than later."
2. "DNA, you know, is Midas' gold. Everybody who touches it goes mad."
3. "Then they ask you, 'What is the significance of DNA for mankind, Dr. Watson?'"
"Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid," by J.D. Watson and F.H.C. Crick. Nature, 171 (25 April 1953), pages 737-738
"Genetical Implications of the Structure of Deoxyribose Nucleic Acid," by J.D. Watson and F.H.C. Crick. Nature, 171 (30 May 1953): 964-967
On the State of Molecular Biology Early in the 1970s
4. On T.H. Morgan's deviation and the secret of life
Part II: RNA The Functions of the Structure: The breaking of the genetic code, the discovery of the messenger
5. "The number of the beast"
6. "My mind was, that a dogma was an idea for which there was no reasonable evidence. You see?!"
7. "The gene was something in the minds of people as inaccessible as the material of the galaxies."
8. "He wasn't a member of the club."
Part III: PROTEIN Structure and Function: The solution of how protein molecules work.
9. "As always, I was driven on by wild expectations."
10. "I have discovered the second secret of life."
CONCLUSION, 1978: "Always the same impasse"
EPILOGUE: "We can put duck and orange DNA togetherwith a probability of one."
AFTERWORD I: In Defense of Rosalind Franklin: The myth of the wronged heroine
AFTERWORD II: What Did Erwin Chargaff Contribute?
AFTERWORD III: Dawn of The Eighth Day