Synopses & Reviews
This proven and well-tested laboratory manual for organic chemistry students contains procedures for both miniscale (also known as small scale) and microscale users. This lab manual gives students all the necessary background to enter the laboratory with the knowledge to perform the experiments with confidence. For the microscale labs, experiments were chosen to provide tangible quantities of material, which can then be analyzed. Chapters 1-2 introduce students to the equipment, record keeping, and safety of the laboratory. Chapters 3-6, and 8 are designed to introduce students to laboratory techniques needed to perform all experiments. In Chapters 7 and 9 through 20, students are required to use the techniques to synthesize compounds and analyze their properties. In Chapter 21, students are introduced to multi-step syntheses of organic compounds, a practice well known in chemical industry. In Chapter 23, students are asked to solve structures of unknown compounds. The new chapter 24 introduces a meaningful experiment into the textbook that reflects the increasing emphasis on bioorganic chemistry in the sophomore-level organic lecture course. This experiment not only gives students the opportunity to accomplish a mechanistically interesting and synthetically important coupling of two a-amino acids to produce a dipeptide but also provides valuable experience regarding the role of protecting groups in effecting synthetic transformations with multiple functionalized molecules.
This proven laboratory manual for organic chemistry contains procedures for both miniscale (also known as small scale) and microscale users. EXPERIMENTAL ORGANIC CHEMISTRY covers the background and laboratory techniques readers need to perform the book's experiments with confidence. Chapters show readers how to use the book's techniques to synthesize compounds and analyze their properties, complete multi-step syntheses of organic compounds, and solve structures of unknown compounds.
Table of Contents
1. Introduction, Record Keeping, and Laboratory Safety. 2. Techniques and Apparatus. 3. Solids: Recrystallization and Melting Points. 4. Liquids: Distillation and Boiling Points. 5. Extraction. 6. Chromatography. 7. Stereoisomers. 8. Spectral Methods. 9. Alkanes. 10. Alkenes. 11. Alkynes. 12. Dienes: The Diels-Alder Reaction. 13. Kinetic and Thermodynamic Control of a Reaction. 14. Nucleophilic Aliphatic Substitution: Preparation for Alkyl Halides. 15. Electrophilic Aromatic Substitution. 16. Oxidation of Alcohols and Carbonyl Compounds. 17. Reduction Reactions of Double Bonds: Alkenes, Carbonyl Compounds, and Imines. 18. Reactions of Carbonyl Compounds. 19. Organometallic Chemistry. 20. Carboxylic Acids and Their Derivatives. 21. Multistep Organic Synthesis. 22. Polymers. 23. Carbohydrates. 24. á-Amino Acids and Peptides. 25. Identifying Organic Compounds. 26. The Literature of Organic Chemistry.