Synopses & Reviews
The incorporation of Green Chemistry is a relatively new phenomenon in the drug discovery discipline, since the scale that chemists operate on in drug discovery is smaller than those of process and manufacturing chemistry. The necessary metrics are more difficult to obtain in drug discovery due to the diversity of reactions conducted. However, pharmaceutical companies are realizing that incorporation of green chemistry techniques at earlier stages of drug development can speed the development of a drug candidate.
Written by experts who have pioneered green chemistry efforts within their own institutions, this book will provide a practical guide for both academic and industrial labs wanting to know where to start with introducing greener approaches for greatest return on investment.
The Editors have taken a comprehensive approach to the topic, covering the entire drug discovery process from molecule conception, through synthesis, formulation and toxicology with specific examples and case studies where green chemistry strategies have been implemented. Emerging techniques for performing greener drug discovery chemistry are addressed as well as cutting-edge topics like biologics discovery and continuous processing. Moreover, important surrounding issues such as intellectual property are included.
This book will serve as a practical guide for both academic and industrial chemists who work across the breadth of the drug discovery discipline. Ultimately, readers will learn how to incorporate green chemistry strategies into their everyday workflow without slowing down their science.
Synopsis
Pharmaceutical companies are realizing that incorporation of green chemistry techniques at earlier stages of drug development can speed the development of a drug candidate. Edited by experts who have pioneered green chemistry efforts within their own institutions, this book provides a practical guide for both academic and industrial labs wanting to know where to start with introducing greener approaches and where to channel efforts for greatest return on investment. This book takes a comprehensive approach to the topic covering surrounding issues such as intellectual property. It covers the entire drug discovery process from molecule conception, through synthesis, formulation and toxicology with specific examples and case studies where green chemistry strategies have been implemented. Also addressed is green chemistry in biologics discovery, a cutting-edge topic. Ultimately, readers will learn how to incorporate green chemistry strategies into their everyday workflow without slowing down their science.
Synopsis
A practical guide for academic and industrial chemists to incorporating Green Chemistry principles into the drug discovery discipline and its everyday workflows with maximum benefit.
About the Author
Helen F Sneddon is a medicinal chemist as GlaxoSmithKline, UK, where she founded and leads the GSK Green Chemistry Performance Unit, which looks at improving the environmental sustainability of research and development, and the routes arising from it.WCA Environment, UK
Table of Contents
An Overview of Pharmaceutical Green Chemistry; The Business Case for Green Chemistry in Drug Discovery; Barriers to Adopting Green Chemistry in Drug Discovery; Green Chemistry and Molecular Design; Green Chemistry and Laboratory Regulations; Green Toxicology for Laboratory Chemists; Green Chemistry and Intellectual Property; Greening Your Laboratory Reactions; Greener Solvent Usage for Discovery Chemistry; Recycle and Reuse in the Laboratory; Continuous Processing in Drug Discovery; Co Crystals as Green Active Pharmaceutical Ingredients; Green Chemistry Tools for Drug Discovery: E-Notebooks and Apps; Green Chemistry and Biological Drug Discovery; Green Formulations for Drug Discovery; Green Chemistry and High Throughput Screening; Green Chemistry and Synthetic Biology; Green Chemistry and Laboratory Safety.