Synopses & Reviews
This monograph covers the entire field of blood group serology, with its main emphasis on the chemical and biochemical basis of blood group specificity. Full consideration is given to molecular biology investigations, in particular to studies on the structure of blood group genes and the molecular biological basis of alleles and rare blood group variants, whereby relevant literature up to the year 2000 is covered. The text is supplemented by numerous illustrations and tables, and detailed reference lists. The five years since the publication of the first edition have brought further advances in blood group research. Thanks to modern molecular biology, scientists have not only been able to identify the bearer molecules of many more blood groups, they have clarified the molecular basis of a number of further blood group specifities as well. This book offers a concise survey for use by blood bankers and researchers in biochemistry, blood group serology, immunohematology, forensic medicine, population genetics, and anthropology.
Review
"... This book is well organized, accurate ... Helmut Schenkel-Brunner is to be congratulated on compiling and presenting the information in a clear and consice manner ... "Human blood groups: chemical and biochemical basis of antigen specificity" is a useful reference book for the shelf of those interested in understanding the biochemical and genetical aspects of blood group antigens." Human Genetics 2001
Synopsis
As President and organiser of the 26th Congress of the International Society pf Blood Transfusion 'ISBT 2000', I am pleased to introduce this work on the biochemistry of human blood groups, which will serve as a valuable complement to blood group serology work. For this new edition the author has singlehandedly covered virtually all blood group research published before the current year. It is my firm belief that all participants in the ISBT conference will find this book a highly useful addition to their scientific libraries. Vienna, April 2000 W.R. Mayr Congress President Preface This revised and updated edition of the monograph on the chemistry and biochemistry of human blood groups is being published to honour the 1 Oath anniversary of Dr. Karl Landsteiner's discovery of human blood groups here in Vienna. Five years have passed since publication of the first edition, and in this time research on the biochemistry of human blood groups has reached staggering proportions. Thanks to extensive molecular biological applications, research groups have identified the bearer molecules of even more blood groups, and are now able to clarify the molecular basis of a vast number of blood group specificities. Human blood group research has become one of the most fruitful of all biochemical research fields. While this development is immensely gratifying to a researcher like myself, who has worked in human blood groups for the past 34 years, coping with the close to overwhelming number of publications has proved a highly challenging task.
Synopsis
This monograph covers the entire field of blood group serology, with its main emphasis on the chemical and biochemical basis of blood group specificity. Full consideration is given to molecular biology investigations, in particular to studies on the structure of blood group genes and the molecular biological basis of alleles and rare blood group variants, whereby relevant literature up to the year 2000 is covered. The text is supplemented by numerous illustrations and tables, and detailed reference lists.
Description
Includes bibliographical references and index.
Table of Contents
INHALT LANG:IntroductionGlycoconjugatesGlycolipids; GlycoproteinsBiosynthesis of GlycoconjugatesBiosynthesis of Glycoproteins; Biosynthesis of Glycosphingoliopids; Regulation of Chain StructureErythrocyte MembraneConstituents of the Erythrocyte Membrane; Molecular Architecture of the Erythrocyte Membrane; Architecture of the Membranes of Nucleated CellsABO(H) SystemGenetics; Antisera and Lectins; Blood Group ABH Substances; Biosynthesis of ABH Antigens and its Genetic Regulation; ABH Subgroups and VariantsLewis System and the Antigens Lex and LeyGenetics; Antisera and Lectins; Blood Group Lewis Substances; Biosynthesis of Blood Group Lewis Determinants; Antigens Lex and LeyAntigens I and iAntisera; Blood Group I and i Determinants; Blood Group I and i Substances; Expression of I and i Activity During Embryonic Development and under Various Pathological Conditions; Biosynthesis of I and i Determinant StructuresP SystemAntisera and Lectins; Blood Group P Substances; Biosynthesis of the Blood Group P AntigensMNS SystemGenetics; Antisera and Lectins; Blood Group MNS Substances; Structure and Organisation of the MNS Gene Complex; Chemical Structures of the Main Determinants of the MNS System; Rare Variants of the MNS Antigens; MNS-Deficient Phenotypes, and Antigens Associated with MNS SystemPolyagglutinationAntisera and Lectins; T Antigen; Tk Antigen; Th Antigen; Tx Antigen; Tn Antigen; VA and NORSid and CadAntisera and Lectins; Sda Active Substances; Cad Active Substances; Investigations on the Biosynthesis of Sda and Cad DeterminantsSlalic Acid-Containing Receptors for Cold AgglutininsAntisera; Structures of Antigenic Determinants; Occurrence of Pr, Gd, and Sa Antigens on Other Cell Types; Other Receptors for Cold AgglutininsRh SystemGenetics; Rh Antisera, Chemical Properties of Rh Antigens; Number of Rh Proteins; Molecular Biological Investigations; Rh Antigens and PhenotypesLandsteiner-Wiener SystemChido / Rodgers SystemDuffy SystemKell SystemAntibodies; Kell-Deficient Phenotypes; Kell Glycoprotein; Kell Alleles; Kx AntigenGerbich SystemGlycophorin C and Glycophorin D; The Antigen CharactersGe1, Ge2, Ge3, and Ge4, and the Lsa Determinant; Wb (Webb); Dha (Duch); Ana (Ahonen)Lutheran SystemDiego SystemAntibodies; The Antigens of the Diego SystemCromer SystemDombrock SystemYt SystemIndian SystemKnops SystemKidd SystemXg SystemColton SystemOK SystemJMH AntigenAntigens of the Major Histocompatibilitiy Complex (HLA Antigens)Genetics; HLA Antisera; HLA Gene ProductsHEMPASCarcinoembryonic Antigen (CEA) Family