Synopses & Reviews
According to the most recent clinical oncology data, one out of seven newly diagnosed malignancies worldwide result from infection and chronic inflammation in conjunction with cancer. In Inflammation and Cancer: Methods and Protocols, expert researchers deliver a systematic guide to techniques addressing various aspects of experimental cancer biology, selectively focused on inflammation-mediated tumorigenesis, while promoting improvisations on a per-case basis. Volume 2, Molecular Analysis and Pathways is devoted to an extensive description of experimental strategies aimed at investigating the molecular cross-talks between components of cell signaling chains and their ramifications in diagnostic development and drug target discovery. Written in the highly successful Methods in Molecular Biology™ series format, chapters include brief introductions to their subjects, lists of the necessary materials and reagents, step-by-step laboratory protocols, and a notes section, which examines tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Inflammation and Cancer: Methods and Protocols promises to serve as a vital guide and resource for investigators and clinicians working toward the goal of combatting the estimated 2, 200 inflammation-related oncogenesis fatalities occurring every day.
From the reviews: "Chapters in this volume are designed to be guides to techniques addressing various aspects of experimental cancer biology. ... this volume will earn a place on the lab benches of investigators and clinicians who are studying inflammation-related oncogenesis. ... this book can provide a source of information for establishing new techniques as well as suggestions for investigating particular aspects of tumorigenesis." (Marion C. Cohen, Doody's Review Service, December, 2009)
One out of seven newly diagnosed malignancies worldwide result from infection and chronic inflammation in conjunction with cancer. This book is a guide for fighting the 2,200 inflammation-related oncogenesis fatalities that occur every day.
Table of Contents
Part I. Crossroads of Inflammation and Cancer: Molecular Aspects Chapter 1. Immunohistochemical Analysis of 8-nitroguanine, a Nitrative DNA Lesion, in Relation to Inflammation-Associated Carcinogenesis Yusuke Hiraku and Shosuke Kawanishi Chapter 2. Molecular Analysis of Genetic Instability Caused by Chronic Inflammation Bin Yan, Yuanlin Peng, and Chuan-Yuan Li Chapter 3. Obesity Provides a Permissive Milieu in Inflammation-Associated Carcinogenesis: Analysis of Insulin and IGF Pathways Nomeli P. Nunez, Stephen D. Hursting, Shoshana Yakar, Dan Fowler, and Charles Vinson Chapter 4. Detecting and Modulating the NF-kB Activity in Human Immune Cells: Generation of Human Cell Lines with Altered Levels of NF-kB Fui G. Goh, Helen Banks, and Irina A. Udalova Chapter 5. Inflammation-Related Aberrant Patterns of DNA Methylation: Detection and Role in Epigenetic Deregulation of Cancer Cell Transcriptome Hiromu Suzuki, Minoru Toyota, Yutaka Kondo, and Yasuhisa Shinomura Chapter 6. cDNA Microarray Analysis of Inflammatory Breast Cancer Signatures Steven J. Van Laere, Peter B. Vermeulen, and Luc Y. Dirix Chapter 7. Analysis of the TLR/NF-kB Pathway in Antigen-Presenting Cells in Malignancies Promoted by Inflammation J. Magarian Blander Chapter 8. Induced Nitric Oxide Synthase (iNOS) as a Major Player in the Oncogenic Transformation of Inflamed Tissue Guang-Yu Yang, Sofia Taboada, and Jie Liao Part II. Molecular and Cellular Approaches to Diagnostics and Drug Target Discovery in Inflammation-Related Oncogenesis Chapter 9. Development of a Cell-Based Assay to Quantify the Inflammatory Potential of Test Substances and Screen Compound Libraries for Anti-Cancer Drug Candidates in a High-Throughput Format Serguei V. Kozlov Chapter 10. The NF-kB Transcription Factor Pathway as a Therapeutic Target in Cancer: Methods for Detection of NF-kB Activity Claudio Mauro, Francesca Zazzeroni, Salvatore Papa, Concetta Bubici, and Guido Franzoso Chapter 11. Inhibiting Pro-Inflammatory NF-kB Signaling Using Cell-Penetrating NEMO Binding Domain (NBD) Peptides Lisa A. Madge and Michael J. May Chapter 12. Quantitative Measurement of Cytokine Expression in Synoviocytes Derived from Rheumatoid Arthritis Patients Scott Thomson and Irina A. Udalova Chapter 13. Molecular Characterization of Inflammation-Induced JNK/c-Jun Signaling Pathway in Connection with Tumorigenesis Bozena Kaminska Chapter 14. Molecular Characterization of STAT Signaling in Inflammation and Tumorigenesis Alicja Adach, Aleksandra Ellert-Miklaszewska, and Bozena Kaminska Chapter 15. Inflammation and Tumor Progression: A Lesson from TNF-a-Dependent FAK Signaling in Cholangiocarcinoma Naing Naing Mon, Toshio Kokuryo, and Michinari Hamaguchi Chapter 16. Cyclooxygenase Inhibitors Induce Colon Cancer Cell Apoptosis Via PPARd -> 14-3-3e Pathway Kenneth K. Wu and Jun-Yang Liou Chapter 17. PPARb/d Agonist Increases the Expression of PGE2 Receptor Subtype EP4 in Human Lung Carcinoma Cells Jeffrey D. Ritzenthaler, Jesse Roman, and ShouWei Han Chapter 18. Investigating Macrophage and Malignant Cell Interactions In vitro Thorsten Hagemann and Toby Lawrence Chapter 19. Cellular Magnetic Resonance Imaging Using Superparamagnetic Anionic Iron Oxide Nanoparticles: Applications to In Vivo Trafficking of Lymphocytes and Cell-Based Anti-Cancer Therapy Pierre Smirnov Chapter 20. Application of Phage Display to Discovery of Tumor-Specific Homing Peptides: Developing Strategies for Therapy and Molecular Imaging of Cancer Seung-Min Lee, Eun-Ju Lee, Hai-Yan Hong, Tae-Gyun Kwon, In-San Kim, and Byung-Heon Lee Chapter 21. Molecular Basis of Histone Deacetylase Inhibitors as New Drugs for the Treatment of Inflammatory Diseases and Cancer Rainer Glauben and Britta Siegmund Chapter 22. Peptide YY (PYY) Mediates Inhibition of Tumor Growth and Inflammation Julie A. Alosi and David W. McFadden