Synopses & Reviews
The volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. The cardiovascular and respiratory systems are tightly coupled, as their primary function is to supply oxygen to and remove carbon dioxide from the body's cells. Because physiological conduits have deformable and reactive walls, macroscopic flow behavior and prediction must be coupled to phenomenological models of nano- and microscopic events in a corrector scheme of regulated mechanisms when the vessel lumen caliber varies markedly. Therefore, investigation of flows of blood and air in physiological conduits requires an understanding of the biology, chemistry, and physics of these systems together with the mathematical tools to describe their functioning. Volume 4 is devoted to major sets of intracellular mediators that transmit signals upon stimulation of cell-surface receptors.
This book reviews signaling pathways in the regulation of circulatory and respiratory function, integrating biology, chemistry, and physics for a multidisciplinary view of physiological flows. It describes ion and molecular carriers and receptors.
Table of Contents
1. Introduction 2. Signaling Lipids 3. Preamble to Cytoplasmic Protein Kinases 4. Cytoplasmic Protein Tyrosine Kinases 5. Cytoplasmic Protein Serine/Threonine Kinases 6. Dual-Specificity Protein Kinases 7. Mitogen-Activated Protein Kinase Module 8. Dual-Specificity Protein Kinases 9. Guanosine Triphosphatases and Their Regulators 10. Other Major Types of Signaling Mediators 11. Signaling Pathways 12. Conclusion References List of Currently Used Prefixes and Suffixes List of Aliases Complementary Lists of Notations Index