Synopses & Reviews
One of the foundations of molecular biology is how the interactions of proteins with DNA control many aspects of gene expression. Since the mid-20th century discoveries of the lac repressor and operator and the competition between the cI and cro proteins for the same segment of DNA, we have learned an enormous amount about the interactions of proteins with DNA and their control of fundamental processes in the cell. An Introduction to ProteinDNA Interactions: Structure, Thermodynamics, and Bioinformatics describes what we know about proteinDNA interactions from the complementary perspectives of molecular and structural biology and bioinformatics and how each perspective informs the others. A particular emphasis is on how insights from experimental work can be translated into specific computational approaches to create unified view of the field and a fuller understanding of proteinDNA interactions.
Table of Contents
Preface
1 Importance of Protein-DNA Interactions
STRUCTURE
2 The Structure of DNA
3 Protein Structure and DNA Recognition
4 Sequence-Specific Interactions in Protein-DNA Complexes
THERMODYNAMICS
5 Binding Affinity, Cooperativity, and Specificity
6 Energetics and Kinetics of Binding
BIOINFORMATICS
7 Bioinformatics of DNA-Binding Sites
8 Bioinformatics of Transcription Factors and Recognition Models
9 Transcriptional Genomics
Index