Synopses & Reviews
Contained within this short volume are some of the Key Clinical Trials relating to the medical treatment of erectile dysfunction (ED). In an attempt to understand the potential significance, a critique of the studies' strengths and weaknesses is included as well as a diagrammatic summary of the trial design and key results. Most of the studies have appeared in peer group reviewed journals and each trial included has been done so on the basis of the influence it will have on the treatment of ED. With the recent launch and continuing developments of new drugs in this field, the management of ED has become an increasingly important aspect of urological practice. It is estimated that over 20 million men in Europe alone suffer at some time in their life from ED. This is the first book to bring together in a single volume a critical review of all the major trials in ED. It will be an essential reference for both clinicians and research workers in urology, sexual dysfunction and related disorders.
Synopsis
This book represents a critical appraisal of the major clinical trials that have had a significant impact on clinical research and practice during the last decade. Each trial follows a strict format, starting with reference to the original source of publication, details on the key investigators and their methods of research. The strengths and weaknesses of each trial are discussed as well as their influence on clinical practice. Articles are complemented by a diagrammatic summary of the trial design and the key findings. It is estimated that over 20 million men in Europe alone suffer at some time in their life from erectile dysfunction (ED). This is the first book to bring together in a single volume a critical review of all the major trials in ED. It will be an essential reference for both clinicians and research workers in urology, sexual dysfunction and related disorders.
Table of Contents
Yohimbine: first oral pharmacotherapy.- Phenoxybenzamine: an early intracavernosal agent.- Intracavernosal therapy: potential of vasorelaxant agents.- Intracavernosal therapy: confirmation of response.- Yohimbine: modest effects as an oral monotherapy.- Intracavernosal alprostadil: rationale for use.- Intracavernosal alprostadil: long-term efficacy & safety.- Intracavernosal therapy: combination of vasoactive agents.- Intraurethral alprostadil.- Alprostadil: intracavernosal versus intraurethral.- Sildenafil: pilot study of first effective oral agent.- Sildenafil: utility confirmed.- Apomorphine SL: pilot study of an alternative oral agent.- Apomorphine SL: a viable alternative oral agent.- Phentolamine: a potential oral agent.- Testosterone therapy in androgen defficient men.- Psychotherapy.- Vacuum device.- Penile prostheses.