Synopses & Reviews
Synopsis
A. Model Systems of Kidney Development and Disease: 1. Madhu Tapadia
[email protected]: Naveen Gautam
[email protected] Topic: Drosophila Malpighian Tubule Development
2. Alan Davidson
[email protected] Co-author: Richard NaylorTopic: Zebrafish Nephron Formation
3. Rebecca Wingert
[email protected] Co-author: graduate studentTopic: Zebrafish as a model of kidney disease
4. Kelly McLaughlin
[email protected] Co-author: Shoshoni CaineTopic: Use of Xenopus frogs to study renal development/repair
B. Cell Renewal, Differentiation and Fate in Nephrogenesis: 5. Zubaida Saifudeen
[email protected] Topic: p53-Energy metabolism directed renewal vs differentiation
6. Peter Hohenstein
[email protected]: Derya Ozdemir
[email protected] Topic: Wilms' tumors and differentiation (tentative)
7. Leif Oxburgh
[email protected] Co-authors: Deepthi Muthukrishnan, Aaron Brown, Sarah McCarthy, Jennifer FettingTopic: Growth factor regulation in the nephrogenic zone
8. Wenzheng Zhang
[email protected]: Lihe Chen and Paul Higgins Topic: Development and Diseases of the Collecting Duct
9. Norman Rosenblum
[email protected]: Christopher Rowan and Sepideh Sheybani DelouiTopic: Origin and function of the renal stroma in health and disease
C. Nephron Morphogenesis and Maintenance: 10. Ian Smyth
[email protected] Co-author: Kieran Short
[email protected] Topic: integrating tissue morphology and cellular events during branching morphogenesis in the developing kidney
11. Kimberly Reidy
[email protected] Topic: Polarity Proteins in Kidney Development and Disease (tentative)
12. Pamela Tran
[email protected] Topic: Cilia in Cystic Kidney Disease
13. Brad Yoder
[email protected] Co-authors: Cheng Song
[email protected] Kurt A Zimmerman
[email protected] Topic: Inflammation and Fibrosis in Polycystic Kidney Disease
14. Ana Sofia Cruz
[email protected]: Arvind Bhimaraj and Keith YoukerTopic: Endothelial to Mesenchymal Transition in Kidney Fibrosis
Synopsis
Kidney Development and Disease brings together established and young investigators who are leading authorities in nephrology to describe recent advances in three primary areas of research. The first section describes the use of animal models as powerful tools for the discovery of numerous molecular mechanisms regulating kidney development. The second section focuses on nephric cell renewal and differentiation, which lead to diverse cell fates within the developing kidney, and discusses diseases resulting from the aberrant regulation of the balance between cell fate decisions. The final section concentrates on morphogenesis of the developing kidney and its maintenance after formation as well as the diseases resulting from failures in these processes.
Kidney form and function have been extensively studied for centuries, leading to discoveries related to their development and disease. Recent scientific advances in molecular and imaging techniques have broadened our understanding of nephron development and maintenance as well as the diseases related to these processes.