Synopses & Reviews
Marine bioprospecting is a highly topical subject, but, as yet, the marine ecosystem is a relatively unexplored source of natural bioactive substances with potential therapeutic activity. This book addresses the use of marine enzymes in biocatalysis.
The author, a leading sciencist within academic and industrial fields, initially examines the nature and level of interest in marine biological diversity, and outlines the fundamentals of biocatalysis. He details sources of marine enzymes and analyzes examples from both chemical and stereochemical viewpoints of catalysis, including microbial enzymes and animal or plant sources before exploring the future potential of marine bioprospecting in biocatalysis.
-Offers a molecular view which fully explains the enzymatic aspects of reactions, particularly regarding biocatalytic characteristics and descriptions of bioprocesses
-Describes methods to help avoid destructive, large-scale collections of marine biomass for enzyme production
About the Author
Antonio Trincone is Senior Researcher at the Istituto di Chimica Biomolecolare (ICB), Italy.
Table of Contents
Introduction: Examination of marine biological diversity; Commercial interest in genetic resources from the deep sea; Fundamental principles of biocatalysis (benefits of adopting enzymatic routes rather than chemical approaches to production of pharmaceuticals, etc.); Known applications of marine enzymes
Source of marine enzymes:Marine extremophiles; Marine biotechnology; Bioprocess approaches to production of marine enzymes; Enzymes from marine fungi; Marine metagenomic approaches for identification of new biocatalysts
Processes and biocatalytic characteristics
Bioprocesses: Marine biomarkers in pollution monitoring; Potent enzymatic activities useful for unreactive centers; (bioremediation or enzymatic transformation of marine biotoxins); Waste management research concerning fishery and seafood related industries; Commercially viable exploitation of marine enzymes from different sources; Proteinase in squid liver and other case studies
Biocatalytic characteristics: Description of known biocatalytic characteristics; Studies of marine enzyme properties useful in biocatalysis: Different stereoselectivity in oxidoreductases compared to terrestrial counterparts; Stereoselective synthesis using marine enzymes; Marine laccases; Resistance to high salt concentration and/or organic solvents; marine carbohydrate active enzymes in the hydrolysis of carbohydrate polymers (exploitation of marine biomasses, etc,), and in synthesis of specialty molecules in oligosaccharide domain; Biosynthesis and degradation of bioactive imidazole-related dipeptides; Other marine hydrolases