Synopses & Reviews
Marks’ Essentials of Medical Biochemistry takes a patient-oriented approach that links biochemistry to physiology and pathophysiology, allowing students to apply fundamental concepts to the practice of medicine. Based on the established text,
Marks’ Basic Medical Biochemistry, Marks’ Essentials is streamlined to focus only on the most essential biochemical concepts, while maintaining intuitively organized chapters centered on hypothetical patient vignettes and helpful icons for smooth navigation.
- Full-color illustrations of chemical structures and biochemical pathways elucidate core concepts and enhance understanding of the text
- Hypothetical patient vignettes ensure clinical relevance and help connect biochemistry to human health and disease
- Helpful icons guide you through each chapter and identify key concepts such as signs and symptoms, clinical pearls, treatment options and outcomes, and more
- Chapter Outlines and Key Points allow readers to preview and review chapter content
- End-of-Chapter Review Questions and Summary Disease Tables highlight the take-home messages and reinforce knowledge
Synopsis
Based on the Second Edition of Marks' Basic Medical Biochemistry: A Clinical Approach, Marks' Essentials of Medical Biochemistry has been streamlined to focus on only the most essential biochemical concepts important to medical students. The authors present facts and pathways to emphasize how the underlying biochemistry is related to the body's overall physiological functions. This text presents patients to the students as the biochemistry is being discussed, which strengthens the link between biochemistry and medicine and allows the student to learn about this interaction as the biochemistry is presented. Each chapter includes clinical and biochemical notes and comments, questions and answers to encourage further thinking, and suggested references for those who would like to pursue a particular topic in more depth.
Table of Contents
FUEL METABOLISM
An Overview of Fuel Metabolism
CHEMICAL AND BIOLOGICAL FOUNDATIONS OF BIOCHEMISTRY
Water, Acids, Bases, and Buffers
Structures of the Major Compounds of the Body
Amino Acids in Proteins
Structure-Function Relationships in Proteins
Enzymes as Catalysts
Regulation of Enzymes
Cell Structure and Signaling by Chemical Messengers
GENE EXPRESSION AND PROTEIN SYNTHESIS
Structure of the Nucleic Acids
Synthesis of DNA
Transcription: Synthesis of RNA
Translation: Synthesis of Proteins
Regulation of Gene Expression
Use of Recombinant DNA Techniques in Medicine
OXIDATIVE METABOLISM AND THE GENERATION OF ATP
Cellular Bioenergetics: ATP and O2
Tricarboxylic Acid Cycle
Oxidative Phosphorylation, Mitochondrial Function, and Oxygen Radicals
Generation of ATP from Glucose: Glycolysis
Oxidation of Fatty Acids and Ketone Bodies
CARBOHYDRATE METABOLISM
Basic Concepts in the Regulation of Fuel Metabolism by Insulin, Glucagons and Other Hormones
Digestion, Absorption, and Transport of Carbohydrates
Formation and Degradation of Glycogen
Pathways of Sugar Metabolism: Pentose Phosphate Pathway, Fructose and Galactose Metabolism
Synthesis of Glycosides, Lactose, Glycoproteins, and Glycolipids
Gluconeogenesis and Maintenance of Blood Glucose Levels
LIPID METABOLISM
Digestion and Transport of Dietary Lipids
Synthesis of Fatty Acids, Triacylglycerols, and the Major Membrane Lipids
Cholesterol Absorption, Synthesis, Metabolism and Fate
Integration of Carbohydrate and Lipid Metabolism
NITROGEN METABOLISM
Protein Digestion and Amino Acid Absorption
Fate of Amino Acid Nitrogen: Urea Cycle
Synthesis and Degradation of Amino Acids
Tetrahydrofolate, Vitamin B12, and S-Adenosylmethionine
Purine and Pyrimidine Metabolism
Intertissue Relationships in the Metabolism of Amino Acids