Synopses & Reviews
During the last ten years, remarkable progress has occurred in the study of molecular evolution. Among the most important factors that are responsible for this progress are the development of new statistical methods and advances in computational technology. In particular, phylogenetic analysis of DNA or protein sequences has become a powerful tool for studying molecular evolution. Along with this developing technology, the application of the new statistical and computational methods has become more complicated and there is no comprehensive volume that treats these methods in depth. Molecular Evolution and Phylogenetics fills this gap and present various statistical methods that are easily accessible to general biologists as well as biochemists, bioinformatists and graduate students. The text covers measurement of sequence divergence, construction of phylogenetic trees, statistical tests for detection of positive Darwinian selection, inference of ancestral amino acid sequences, construction of linearized trees, and analysis of allele frequency data. Emphasis is given to practical methods of data analysis, and methods can be learned by working through numerical examples using the computer program MEGA2 that is provided.
Synopsis
This book presents the statistical methods that are useful in the stud y of molecular evolution and illustrates how to use them in actual dat a analysis. It is appropriate for graduate students and researchers (a ssuming a basic knowledge of evolution, moecular biology, and elementa ry statistics), allowing many investigators to incorporate refined sta tistical analysis of large-scale data in their own work.
Synopsis
During the last ten years, remarkable progress has occurred in the study of molecular evolution. Among the most important factors that are responsible for this progress are the development of new statistical methods and advances in computational technology. In particular, phylogenetic analysis of DNA or protein sequences has become a powerful tool for studying molecular evolution. Along with this developing technology, the application of the new statistical and computational methods has become more complicated and there is no comprehensive volume that treats these methods in depth. Molecular Evolution and Phylogenetics fills this gap and present various statistical methods that are easily accessible to general biologists as well as biochemists, bioinformatists and graduate students. The text covers measurement of sequence divergence, construction of phylogenetic trees, statistical tests for detection of positive Darwinian selection, inference of ancestral amino acid sequences, construction of linearized trees, and analysis of allele frequency data. Emphasis is given to practical methods of data analysis, and methods can be learned by working through numerical examples using the computer program MEGA2 that is provided.
Description
Includes bibliographical references (p. 301-328) and index.
Table of Contents
Numerical Examples
1. Molecular Basis of Evolution
2. Evolutionary Change of Amino Acid Sequences
3. Evolutionary Change in DNA Sequences
4. Synonymous and Nonsynonymous Nucleotide Substitutions
5. Phylogenetic Trees
6. Phylogenetic Inference: Distance Methods
7. Phylogenetic Inference: Maximum Parsimony Methods
8. Phylogenetic Inference: Maximum Likelihood Methods
9. Accuracies and Statistical Tests of Phylogenetic Trees
10. Molecular Clocks and Linearized Trees
11. Ancestral Nucleotide and Amino Acid Sequences
12. Genetic Polymorphism and Evolution
13. Population Trees from Genetic Markers
14. Perspectives
Appendices
References
Index