Synopses & Reviews
Over the last fifteen years, N-heterocyclic carbenes (NHCs) have mostly been used as ancillary ligands for the preparation of transition metal-based catalysts. Compared to phosphorus-containing ligands, NHCs tend to bind more strongly to metal centres, avoiding the necessity for the use of excess ligand in catalytic reactions. The corresponding complexes are often less sensitive to air and moisture, and have proven remarkably resistant to oxidation. Recent developments in catalysis applications have been facilitated by the availability of carbenes stable enough to be bottled, particularly for their use as organocatalysts. This book shows how N-heterocyclic carbenes can be useful in various fields of chemistry and not merely laboratory curiosities or simple phosphine mimics. NHCs are best known for their contribution to ruthenium and palladium-catalysed reactions but the scope of this book is much broader. The synthesis of NHC ligands and their corresponding metal complexes are covered in depth. Moreover, the biological activity of NHC-containing complexes, as well as an overview of their theoretical aspects are included. Such metal species are further examined, not only in terms of their catalytic applications, but also of their stereoelectronic parameters and reactivity/stability. Finally, special attention is given to the hot topic of organocatalysis. The book will be of interest to postgraduates, academic researchers and those working in industry.
Synopsis
This book shows how N-heterocyclic carbenes can be useful in various fields of chemistry and not merely laboratory curiosities or simple phosphine mimics. NHCs are best known for their contribution to ruthenium and palladium catalysed reactions but the scope of this book is much broader. The synthesis of NHC ligands and their corresponding metal complexes are covered in depth. Such metal species are examined, not only in terms of their catalytic applications, but also their stereoelectronic parameters. Finally, special attention is given to the hot topic of organocatalysis. In this last chapter, particular emphasis is given to the novel reactivities being developed such as 1,2-additions, opening of small rings and O2 functionalization. The book will be of interest to postgraduates and those working in industry.
Synopsis
Though NHCs are best known in the context of ruthenium and palladium catalysed reactions, the scope of this book is much broader, showing how NHCs can be useful in various fields of chemistry and not merely as laboratory curiosities or simple phosphine mimics.
Synopsis
Aimed at postgraduates and those working in industry, this book details the uses of N-heterocyclic carbenes in various fields of chemistry.
About the Author
ACADEMIC AND PROFESIONAL RECORD: Since 2006 Scientific Group Coordinator in the group of Prof. Steven P. Nolan, ICIQ, Tarragona 2004 - 2006 Post-Doctoral Fellowship in the group of Prof. S. P. Nolan, University of New Orleans, USA and University of Ottawa, Canada 2000 - 2004 Ph.D in Organic Chemistry 'Synthesis of a model of cycles A and B of 10-silatestosterone' under the supervision of Dr. Luis Blanco, Universit� de Paris Sud, Orsay, France SELECTED PUBLICATIONS: Dr. D�ez-Gonz�lez has 24 publications (including the ones in press) in peer-reviewed journals, which have received 293 citations to date. Among these publications, she is the first author in 17 and the corresponding author of 8. Her work has also been acknowledged by 15 communications (9 oral and 6 poster) in international conferences.
Table of Contents
Chapter 1: Introduction to N-Heterocyclic Carbenes: Synthesis and Stereoelectronic Parameters; Chapter 2: Computational Studies on the Reactivity of Transition Metal Complexes with N-Heterocyclic Carbene Ligands; Chapter 3: Synthesis, Activation and Decomposition of N-Heterocyclic Carbene-Containing Complexes; Chapter 4: Biologically Active N-Heterocyclic Carbene-Metal Complexes; Chapter 5: Non-Classical N-Heterocyclic Carbene Complexes; Chapter 6: Early Transition and Rare Earth Metal Complexes with N-Heterocyclic Carbenes; Chapter 7: NHC-Iron, Ruthenium, AND Osmium Complexes in Catalysis; Chapter 8: NHC-Cobalt, Rhodium, and Iridium Complexes in Catalysis; Chapter 9: NHC-Palladium Complexes in Catalysis; Chapter 10: NHC-Nickel and Platinum Complexes in Catalysis; Chapter 11: NHC-Copper, Silver AND Gold Complexes in Catalysis; Chapter 12: Oxidation Reaction with NHC Metal Complexes; Chapter 13: Reduction Reactions with NHC-Bearing Complexes; Chapter 14: N-Heterocyclic Carbenes as Organic Catalysts