Synopses & Reviews
Tissue engineering promises to revolutionize the way millions of patients with organ failure or tissue damage are treated. Yet the challenges are significant. Materials synthesis, characterization, design, and application are a central part of tissue engineering. This book provides guidance on these important issues, particularly at the nanoscale.
After an introductory chapter, the book is divided into three parts: The fabrication of nanomaterials for tissue engineering applications, the application of nanomaterials in soft tissue engineering, and the application of nanomaterials in hard tissue engineering. The six chapters in part one review novel techniques, such as layer-by-layer self-assembly, synthesis of carbon based systems, creation of nanofibrous scaffolds, and delivery of growth factors. The following section examines, in particular, vascularized tissue, heart neural tissue, and cartilage and ligaments. The conclusion considers bone, dental, and craniofacial tissues.
"...This volume addresses a previously underserved niche within the spectrum of biomaterials/tissue engineering research...the present contribution remains firmly focused on the challenges and opportunities of nanomaterials applied in tissue engineering."
The Biomaterials Network
Nanomaterial technologies can be used to fabricate high-performance biomaterials with tailored physical, chemical, and biological properties. Nanomaterials are therefore currently the development focus for emerging biomedical technologies such as scaffolding, tissue regeneration, and controlled drug delivery. This important volume provides readers with a thorough overview of this developing field. Opening chapters review the fundamentals of nanomaterials for medical applications and the fundamentals of nanomaterials for tissue engineering. Further contributions look at applications of nanomaterials in soft tissue engineering and review applications of nanomaterials in hard tissue engineering.
About the Author
Akhilesh Gaharwar works at the David H. Koch Institute for Integrative Cancer Research at Massachusetts Institute of Technology (MIT) and Research Fellow in the Wyss Institute for Biologically Inspired Materials at Harvard University, Massachusetts. His research experience spans diverse fields including materials science, chemistry, biology, and microfabrication of polymeric biomaterials and nanocomposites. His current research focus is developing technologies to control the formation of vascularized orthopedic tissues with appropriate microarchitectures as well as regulating stem cell differentiation within microengineered systems.
Shilpa Sant is Assistant Professor of Pharmaceutical Studies at the University of Pittsburgh, Pennsylvania. She has extensive research experience in diverse fields including materials science, polymer chemistry, drug delivery, tissue engineering, natural and synthetic biomaterials and microfabrication.
Matthew Hancock is Research Scientist at the Broad Institute, MIT, leading projects to develop devices for circulating tumor cell (CTC) and sepsis detection and anti-cancer drug screening.
S. Adam Hacking is Director of the Laboratory for Musculoskeletal Research and Innovation (LMRI) at Massachusetts General Hospital. His work is focused on novel methods to fight implant infection, methods to enhance implant fixation, the use of non-invasive techniques to assess skeletal integrity and implant fixation, methods to improve defect healing, fracture healing and allograft incorporation and the use of micro-fabrication techniques to generate bone from its fundamental unit, the osteon.
Table of Contents
Part 1 Fundamental of nanomaterials in tissue engineering
: Biomedical nanomaterials for tissue engineering; Physiochemical characterization of biomedical nanomaterials. Part 2 Fabrication of nanomaterials for tissue engineering applications
: Synthesis of polymeric nanomaterials for biomedical applications; Methods for nano and microtopological patterning in biomaterials engineering; Multilayered films in tissue engineering; Carbon based nanomaterials for tissue engineering; Nanofibrous scaffolds for drug delivery and tissue engineering; Nanomaterials for growth factor delivery in tissue engineering applications
Part 3 Application of nanomaterials in soft tissue engineering: Nanomaterials for engineering vascularized tissue; Nanomaterials for cardiac tissue engineering; Nanomaterials for cartilage tissue engineering; Nanomaterials for ligament tissue engineering
Part 4 Application of nanomaterials in hard tissue engineering: Nanomaterials for hard-soft tissue interfaces; Nanomaterials for bone tissue engineering; Nanomaterials for dental and craniofacial tissue engineering