Table of Contents
Tumour viruses and the identification of oncogenes -- Identification of oncogenes -- How are proto-oncogenes activated by retroviruses? -- How are proto-oncogenes activated in humans? -- DNA tumour viruses -- Normal cell growth and the functions of oncoproteins -- Activation of normal cell growth -- What do oncoproteins do? -- Nuclear oncoproteins -- General consequences of oncogene expression -- Gene therapy for cancer -- Major categories of oncogenes -- Oncogenes transduced by retroviruses -- Oncogenes activated by retroviral insertion -- Oncogenes at chromosomal translocations -- Tumour suppressor genes detected in human tumours -- Functions of oncoproteins -- Chromosome locations of human proto-oncogenes -- Sequence homology within the protein kinase family -- Individual oncogenes -- ABL/BCR -- BCL1, BCL2 and BCL3 -- CBL -- CRK -- CSF1R/Fms -- DBL -- DNA tumour viruses -- Simian vacuolating virus 40 (SV40) -- Polyoma -- Adenovirus -- Papillomavirus -- Epstein-Barr virus (EBV) -- EPH -- ETS -- FGR -- FOS -- FPS/FES -- FYN -- HCK -- HSTF1/Hst-1 and INT2 -- JUN -- KIT -- LCK -- MAS -- MET -- Mil -- MOS -- MYB -- MYC.