Synopses & Reviews
During the last decade the advances in molecular biology have increasingly emphasized the importance of the hydrogen bond in biological interactions. Hydrogen-bonding in assemblages of biological molecules examined from the structural point of view is a main focus of the present book. Hydrogen-bonding is thereby defined in its broadest sense, as many attractive interactions involving a covalently bonded hydrogen atom. The concept of the hydrogen bond structure is developed, as is the role of cooperativity, in stabilizing particular structures and hydrogen-bonding dynamics. The information presented is based on the extraordinary increase in quantitative structural data that has become available from X-ray and neutron diffraction studies of crystal structures involving small and large biological molecules. Included are structural data of particular types of hydrogen bonds as well as data for different types of molecules, such as carbohydrates, purines and pyrimidines, nucleosides and nucleotides, ices and hydrates, cyclodextrins, nucleic acids and proteins.
New textbooks at all levels of chemistry appear with great regularity. Some fields like basic biochemistry, organic reaction mechanisms, and chemical ther- modynamics are well represented by many excellent texts, and new or revised editions are published sufficiently often to keep up with progress in research. However, some areas of chemistry, especially many of those taught at the grad- uate level, suffer from a real lack of up-to-date textbooks. The most serious needs occur in fields that are rapidly changing. Textbooks in these subjects usually have to be written by scientists actually involved in the research which is advancing the field. It is not often easy to persuade such individuals to set time aside to help spread the knowledge they have accumulated. Our goal, in this series, is to pinpoint areas of chemistry where recent progress has outpaced what is covered in any available textbooks, and then seek out and persuade experts in these fields to produce relatively concise but instructive introductions to their fields. These should serve the needs of one semester or one quarter graduate courses in chemistry and biochemistry. In some cases the availability of texts in active research areas should help stimulate the creation of new courses. CHARLES R. CANTOR New York Preface This monograph is based on a review on polynucleotide structures written for a book series in 1976.