Synopses & Reviews
Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy, Third Edition, is a primary textbook for a first course in pharmacology. It offers an integrated mechanism-based and systems-based approach, incorporating the cell biology, biochemistry, physiology, and pathophysiology of organ systems. The completely updated Third Edition features content reflecting current research findings, more than 400 full-color illustrations, Drug Summary Tables, and increased coverage of drug metabolism and the treatment of mycobacterial infections.
Review
Doody's Review, Thomas L Pazdernik, PhD(University of Kansas Medical Center) --
This is a basic pharmacology textbook with an emphasis on the biochemical and cellular mechanisms required for understanding the treatment of pathophysiological conditions.
This is a collaborative effort by Harvard medical faculty and students to prepare a book useful for students who are studying pharmacology as part of their curriculum. This is particularly useful for courses that focus on the biochemical, cellular, and physiological basis of drug action.
The strength of this book lies in the numerous excellent figures that explain the cellular and molecular aspects of drug actions on a physiological basis. This second edition has 100 new or extensively redesigned figures.
The sections on fundamentals of drug development and regulation and frontiers in pharmacology provide a perspective not found in most fundamental pharmacology books.
An access code is provided for an electronic version of the book and images. A companion case-based workbook, Principles of Pharmacology Workbook, by Farrell (Lippincott Williams & Wilkins, 2008), reviews important concepts and drug classes in a question-and-answer format that is valuable for course and board exam review.
Four Stars. Weighted Numerical Score: 93
Synopsis
This primary textbook for a first course in pharmacology offers an integrated, systems-based, and mechanism-based approach to understanding drug therapy. Each chapter focuses on a target organ system, begins with a clinical case, and incorporates cell biology, biochemistry, physiology, and pathophysiology to explain how and why different drug classes are effective for diseases in that organ system.
Over 400 two-color illustrations show molecular, cellular, biochemical, and pathophysiologic processes underlying diseases and depict targets of drug therapy. Each Second Edition chapter includes a drug summary table presenting mechanism, clinical applications, adverse effects, contraindications, and therapeutic considerations. New chapters explain how drugs produce adverse effects and describe the life cycle of drug development.
The fully searchable online text and an image bank are available on thePoint.
Table of Contents
Section 1. Fundamental Principles of PharmacologyChapter 1. Drug-Receptor InteractionsChapter 2. PharmacodynamicsChapter 3. PharmacokineticsChapter 4. Drug MetabolismChapter 5. Drug ToxicityChapter 6and#160; Pharmacogenomicsand#160;Section 2. Principles of NeuropharmacologySection 2a. Fundamental Principles of NeuropharmacologyChapter 7. Principles of Cellular Excitability and Electrochemical TransmissionChapter 8. Principles of Nervous System Physiology and PharmacologySection 2b. Principles of Autonomic and Peripheral Nervous System PharmacologyChapter 9. Cholinergic PharmacologyChapter 10. Adrenergic PharmacologyChapter 11. Local Anesthetic PharmacologySection 2c. Principles of Central Nervous System PharmacologyChapter 12. Pharmacology of GABAergic and Glutamatergic NeurotransmissionChapter 13. Pharmacology of Dopaminergic NeurotransmissionChapter 14. Pharmacology of Serotonergic and Central Adrenergic NeurotransmissionChapter 15. Pharmacology of Abnormal Electrical Neurotransmission in the Central Nervous SystemChapter 16. General Anesthetic PharmacologyChapter 17. Pharmacology of AnalgesiaChapter 18. Pharmacology of Chemical Dependence and Addictionand#160;Section 3. Principles of Cardiovascular PharmacologyChapter 19. Pharmacology of Cholesterol and Lipoprotein MetabolismChapter 20. Pharmacology of Volume RegulationChapter 21. Pharmacology of Vascular ToneChapter 22. Pharmacology of Hemostasis and ThrombosisChapter 23. Pharmacology of Cardiac RhythmChapter 24. Pharmacology of Cardiac ContractilityChapter 25. Integrative Cardiovascular Pharmacology: Hypertension, Ischemic Heart Disease, and Heart Failureand#160;Section 4. Principles of Endocrine PharmacologyChapter 26. Pharmacology of the Hypothalamus and Pituitary GlandChapter 27. Pharmacology of the Thyroid GlandChapter 28. Pharmacology of the Adrenal CortexChapter 29. Pharmacology of ReproductionChapter 30. Pharmacology of the Endocrine PancreasChapter 31. Pharmacology of Bone Mineral Homeostasisand#160;Section 5. Principles of ChemotherapyChapter 32. Principles of Antimicrobial and Antineoplastic PharmacologyChapter 33. Pharmacology of Bacterial Infections: DNA Replication, Transcription, and TranslationChapter 34. Pharmacology of Bacterial and Mycobacterial Infections: Cell Wall SynthesisChapter 35. Pharmacology of Fungal InfectionsChapter 36. Pharmacology of Parasitic InfectionsChapter 37. Pharmacology of Viral InfectionsChapter 38. Pharmacology of Cancer: Genome Synthesis, Stability, and MaintenanceChapter 39. Pharmacology of Cancer: Signal TransductionChapter 40. Principles of Combination Chemotherapyand#160;Section 6. Principles of Inflammation and Immune PharmacologyChapter 41. Principles of Inflammation and the Immune SystemChapter 42. Pharmacology of EicosanoidsChapter 43. Histamine PharmacologyChapter 44. Pharmacology of Hematopoiesis and ImmunomodulationChapter 45. Pharmacology of ImmunosuppressionChapter 46. Integrative Inflammation Pharmacology: Peptic Ulcer DiseaseChapter 47. Integrative Inflammation Pharmacology: AsthmaChapter 48. Integrative Inflammation Pharmacology: Goutand#160;Section 7. Fundamentals of Drug Development and RegulationChapter 49. Drug Discovery and Preclinical DevelopmentChapter 50. Clinical Drug Evaluation and Regulatory ApprovalChapter 51. Systematic Detection of Adverse Events in Marketed Drugsand#160;Section 8. Poisoning by Drugs and Environmental Toxinsand#160;Chapter 52. Poisoning by Drugs and Environmental Toxinsand#160;Section 9. Frontiers in PharmacologyChapter 53. Protein-Based TherapiesChapter 54. Drug Delivery Modalities