Synopses & Reviews
Proteins come in three dimensions, and their structure is generally imposed by the secondary and tertiary structure of the peptide chain. This stage describes the highest level of organization in overall structure assumed by aggregates of more than one polypeptide chain, and this is the fourth folding level of protein building. The eight papers here describe structure-related research, including protein conformational alphabets, a molecular recognition code for proteins, natural conformation of human serum albumin and its changes in pathology, domain motions associates with substrate and inhibitor building and the relevance of distance matrices, the hierarchical order of initiator protein assembly in pre-replication complexes, analytic approaches to comparative modeling of protein structures, modification of the structure of ubiquitin by pentamidine, and structure relatedness through the sequence space of protein molecules. Writers should verify references and data independently.