Synopses & Reviews
The Fifth Edition of this popular text will remain the first choice for those who need current, clinically relevant information on how radiation affects the human body. Written by a practicing, active radiobiologist, the book brings together basic laboratory research and practical, clinical applications. The single-authored, easy-to-read text and informative illustrations ensure comprehension, and summaries at the end of each chapter facilitate quick review.This edition has been reorganized for convenient reference. Brand-new chapters address cancer biology, the clinical response of normal tissues, and gene therapy. Molecular biology is thoroughly integrated into this edition.
Table of Contents
Milestones in Physics and Biology
PART I
The Physics and Chemistry of Radiation Absorption
DNA Strand Breaks and Chromosomal Aberrations
Cell Survival Curves
Radiosensitivity and Cell Age in the Mitotic Cycle
Repair of Radiation Damage and the Dose-Rate Effect
The Oxygen Effect and Reoxygenation
Linear Energy Transfer and Relative Biological Effectiveness
Acute Effects of Total-Body Irradiation
Radioprotectors
Radiation Carcinogenesis
Hereditary Effects of Radiation
Effects of Radiation on the Embryo and Fetus
Radiation Cataractogenesis
Diagnostic Radiology and Nuclear Medicine: Risk Versus Benefit
Radiation Protection
PART II
Molecular Techniques in Radiobiology
Cancer Biology
Dose-Response Relationships for Model Normal Tissues
Clinical Response of Normal Tissues
Model Tumor Systems
Cell, Tissue, and Tumor Kinetics
Time, Dose, and Fractionation in Radiotherapy
Predictive Assays
New Radiation Modalities
Radiosensitizers and Bioreductive Drugs
Gene Therapy
Chemotherapeutic Agents from the Perspective of the Radiation Biologist
Hyperthermia