Synopses & Reviews
Imagine a future in which human beings have become immune to all viruses, in which bacteria can custom-produce everyday items, like a drinking cup, or generate enough electricity to end oil dependency. Building a house would entail no more work than planting a seed in the ground. These scenarios may seem far-fetched, but pioneering geneticist George Church and science writer Ed Regis show that synthetic biology is bringing us ever closer to making such visions a reality.and#160;In Regenesis
, Church and Regis explore the possibilitiesand#151;and perilsand#151;of the emerging field of synthetic biology. Synthetic biology, in which living organisms are selectively altered by modifying substantial portions of their genomes, allows for the creation of entirely new species of organisms. Until now, nature has been the exclusive arbiter of life, death, and evolution; with synthetic biology, we now have the potential to write our own biological future. Indeed, as Church and Regis show, it even enables us to revisit crucial points in the evolution of life and, through synthetic biological techniques, choose different paths from those nature originally took.and#160;Such exploits will involve far more than just microbial tinkering. Full-blown genomic engineering will make possible incredible feats, from resurrecting woolly mammoths and other extinct organisms to creating mirror life forms with a molecular structure the opposite of our own. These technologiesand#151;far from the out-of-control nightmare depicted in science fictionand#151;have the power to improve human and animal health, increase our intelligence, enhance our memory, and even extend our life span.and#160;A breathtaking look at the potential of this world-changing technology, Regenesis
is nothing less than a guide to the future of life.
"Exhilarating and scary facts suffuse this book about bioengineering by leading Harvard genetics professor and entrepreneur Church. The book, written with veteran science writer Regis (What Is Life?), may start slowly for general readers, with its talk on chirality (futuresque virus-resistant mirror-image cells that make new proteins). But when Church describes current work building microbes with minimal genes, the book takes off and eventually soars. Microbes are natural factories. With genetic tweaking, they pump out drugs, biofuels, and green chemicals more efficiently than bricks-and-mortar factories. Church's award-winning firm LS9 makes fuel by inserting genes from four other organisms into E. coli ('the world's fastest machines') that double every 20 minutes. Other researchers have rapidly 'evolved' microbes that make electricity while cleaning waste. Geneticists can boost drug production a billion-fold, and more than 2,000 genes can predict illness. Genetically tweaked 'bugs'' can be more dangerous than bombs. And since technology bans don't work, regulation is key, But 'redesigning nature' should not frighten us: it is 'an inherent part of life,' Church argues in this stimulating book. Illus. Agent: John Brockman, Brockman Inc." Publishers Weekly Copyright PWxyz, LLC. All rights reserved.
and#147;Reading the first book penned by Church, a Harvard biologist and polymath, is like falling down a rabbit hole straight into his fermenting brain. Churchand#8217;s wide-ranging career includes developing novel methods for reading the genetic instruction manual, or genome, of creatures from bacteria to humans. Now he focuses on synthesizing those instructions from scratch.... [A] dizzying survey of how scientists have unearthed the secrets of living organisms and are now using that information to revamp life itself.and#8221;
Robert T. Gonzalez, io9
and#147;[A] phenomenal read.and#8221;
Wall Street Journal
and#147;A definitive account of the advances and business ventures that define this new science [of synthetic biology]and#133;. When history is written centuries from now, it is more likely that writing DNA will be the most enduring innovation [of our age].and#8221;
and#147;Bold and provocativeand#133; Church and Regis offer a behind-the-scenes look at synthetic biology, a rapidly emerging field that is reprogramming the genetic code to create organisms and functions not found in nature. Regenesis tells of recent advances that may soon yield endless supplies of renewable energy, increased longevity and the return of long-extinct species.and#8221;
and#147;The life sciences emerge as the new high-tech in this paean to synthetic biologyand#133;. Each step in the genomeand#8217;s evolution serves as a springboard for expositions of how synthetic biology will revolutionize renewable energy, multivirus resistance, and more.and#8221;
Mike Loukides, Oand#8217;Reilly Radar
and#147;If thereand#8217;s one book that can turn this movement into a full-blown revolution, this is it.and#8221;
Derek Jacoby, Oand#8217;Reilly Radar
and#147;George Church and Ed Regis pull off an exciting and speculative romp through the field of synthetic biology and where it could take us in the not too distant futureand#133;. Regenesis provides an accessible and engaging introduction to the revolutionary potentials of synthetic biology and should be of interest to both experts and a general science audience.and#8221;
and#147;[A]n important and surprisingly accessible book, magisterially structured to intertwine the accelerated history of synthetic biology with its precedents in humanityand#8217;s earlier technological revolutions and in the epochal evolution of life itself. The book packs in a superb short course on lifeand#8217;s molecular workings, enabling the reader to grasp how we can actually contemplate resurrecting mammoths and Neanderthals, brewing biofuel from seawater and sunlight, engineering total immunity to viral infection, storing data in DNA, and more.and#8221;
Nathan Myhrvold, Founder and CEO, Intellectual Ventures
and#147;A delightfully opinionated, visionary and controversial romp through synthetic biology, which is one of the most important technologies of our time."
Eric Topol, Professor of Genomics, The Scripps Research Institute, and author of The Creative Destruction of Medicine
and#147;Literally reinventing nature could provide solutions to intractable problems with the energy supply, global warming, and human health. In Regenesis, George Church, a pioneer and pre-eminent force in promoting our ability to read DNA sequence, now guides us to the future: writing DNA sequence. Teaming up with Ed Regis, Church provides a mind-bending, tour de force account of how this seventh industrial revolution will take hold, and how ultimately the survival of our planet and the human species may rely upon rewriting the code of life. An enthralling journey into the futureand#151;with truly profound implicationsand#151;that should not be missed.and#8221;
Stewart Brand, author of Whole Earth Discipline
and#147;Here you will find the bleeding, screaming, thrilling edges of what is becoming possible with genomic engineering, handsomely framed in the fine-grained fundamentals of molecular biology. It is a combination primer and forecast of what is coming in this and#145;century of biologyand#8217; from the perspective of a leading pioneer in the science.and#8221;
and#147;[An] authoritative, sometimes awe-inspiring bookand#133;. A valuable glimpse of science at the edge.and#8221;
and#147;Exhilarating and scary facts suffuse this book about bioengineering by leading Harvard genetics professor and entrepreneur Churchand#133;. [W]hen Church describes current work building microbes with minimal genes, the book takes off and#150; and eventually soarsand#133;. [A] stimulating book.and#8221;
Steven Pinker, Harvard College Professor of Psychology, Harvard University, and author of How the Mind Works and The Better Angels of Our Nature
and#147;A thoughtful introduction to one of the great frontiers of science, one with the promise of literally saving the world. George Church is one of the most brilliant scientists in the world, and in collaboration with Ed Regis he has written a book that is engaging, readable, and thoroughly fascinating.and#8221;
J. Craig Venter, Chairman and President, J. Craig Venter Institute
and#147;Church and Regis in Regenesis have written a wonderful synopsis of the emerging field of synthetic biology and the implications from renewable plastics to and#145;raising the dead.and#8217; This is a must-read for anyone interested in the future.and#8221;
Misha Angrist, Assistant Professor, Duke Institute for Genome Sciences and Policy, and author of Here is a Human Being
and#147;Regenesis is the most compelling bit of prophecy since the Old Testament first came out in hardback.and#8221;
About the Author
is Professor of Genetics at the Harvard Medical School and member of the Wyss Institute of Biologically Inspired Engineering. He is the director of the Lipper Center for Computational Genetics, the Harvard DOE Genomes-to-Life Center, the NIH Center for Excellence in Genomic Science, and PersonalGenomes.org. Church was the driving force behind the Polonator G.007, a low-cost automated genomic sequencing machine. He lives in Brookline, Massachusetts.
Ed Regis is author of seven science books, most recently What Is Life?: Investigating the Nature of Life in the Age of Synthetic Biology. He lives in Sabillasville, Maryland.