Synopses & Reviews
A wide-ranging account of the immunological mechanisms that underlie many rheumatic diseases, such as rheumatoid arthritis, ankylosing spondylitis and SLE, and the development of effective and rational new therapies.
Review
"The introductory chapter provides an excellent overview of the implications of advances in immunology for understanding the pathogenesis and treatment of rheumatic diseases...The list of authors includes important names in the field...an excellent resource in a single volume for those with clinical or scientific interests in the rheumatic diseases. For the clinician it provides a starting point for understanding the rationale behind current therapeutic approaches in rheumatology and will foster a better understanding of new research in immunology and its application to the treatment of the rheumatic diseases." Journal of Rheumatology"...a good read..." Rheumatology"This is an outstanding contribution. The frequent attempts to show the relevance of immunological principles to disease distinguish this volume from basic immunology and clinical rheumatology books. Indeed, this is an outstanding bridge between perspectives usually provided in both types of books." Doody's Health Sciences Book Review Journal
Review
"The introductory chapter provides an excellent overview of the implications of advances in immunology for understanding the pathogenesis and treatment of rheumatic diseases...The list of authors includes important names in the field...an excellent resource in a single volume for those with clinical or scientific interests in the rheumatic diseases. For the clinician it provides a starting point for understanding the rationale behind current therapeutic approaches in rheumatology and will foster a better understanding of new research in immunology and its application to the treatment of the rheumatic diseases." Journal of Rheumatology"This is an outstanding contribution. The frequent attempts to show the relevance of immunological principles to disease distinguish this volume from basic immunology and clinical rheumatology books. Indeed, this is an outstanding bridge between perspectives usually provided in both types of books." Doody's Health Sciences Book Review Journal
Table of Contents
Implications of advances in immunology for understanding the pathogenesis and treatment of rheumatic disease J. S. Hill Gaston; 1. The role of T cells in autoimmune disease R. J. Moots and K. W. Wucherpfennig; 2. The role of MHC antigens in autoimmunity J. H. Buckner and G. T. Nepom; 3. B cells - formation and structure of autoantibodies A. Rahman, F. K. Stevenson and D. A. Isenberg; 4. Role of CD40 in immune responses P. Lane; 5. Manipulation of the T cell immune system via CD28 and CTLA-4 D. M. Samson and L. S. K. Walker; 6. Lymphocyte antigen receptor signal transduction D. R. Alexander; 7. Role of adhesion mechanisms in inflammation C. Pitzalis; 8. Regulation of apoptosis in rheumatic disorders J. McNally, A. K. Vaishnaw and K. B. Elkon; 9. The role of monokines in arthritisW. B. van den Berg and F. J. J. van de Loo; 10. T lymphocyte sub sets in relation to autoimuune disease F. Ramirez, B. Seddon and D. Mason; 11. Complement receptors J. M. Ahearn and A. M. Rosengard; Index.