Synopses & Reviews
Focussing on the molecular mechanisms that govern mast cell and basophil cell biology and function, this book also provides a comprehensive summary of the field of signal transduction, giving insights into areas that have therapeutic potential. It gives detailed insights into mast cell and basophil growth and development, their activation by allergens, including details of receptor activation and downstream events, and the regulators of morphology and degranulation. The metabolic pathways involved in prostaglandin and leukotriene production are discussed as is the role of transcription factors in mast cell growth and cytokine production. Written by leaders in the field, this volume will provide readers with an up-to-date account of a topic whose rapid progress makes conventional information gathering difficult.
Synopsis
Mast cells and basophils are responsible for inflammatory and allergic reactions. As such, the signals that generate these responses and how their pathways of action work are the focus of much present day research into allergy and inflammation. This book focuses primarily on the molecular mechanisms that govern mast cell and basophil cell biology and function, as well as providing a comprehensive summary of the field of signal transduction and also giving insights into areas that have therapeutic potential. The book provides detailed insights into mast cell and basophil growth and development, their activation by allergens, including details of receptor activation and downstream events, and the regulators of morphology and degranulation. The metabolic pathways involved in prostaglandin and leukotriene production are discussed as is the role of transcription factors in mast cell growth and cytokine production. Written by leaders in the field, this volume will provide the reader with an up-to-date account of a topic where the rapid progress makes conventional information gathering difficult.
Table of Contents
SECTION I. 1. Signals in the Regulation of Mast Cell Growth and Development. 2. The Regulation of Mast Cell and Basophil Development by the c-Kit Ligand. 3. The c-Kit Receptor and the mi Transcription factors.4. Mouse and Rat Models of Mast cell Development. 5. Factors that Affect Human Mast Cell and Basophil Growth. 6. Cytokines, Ras and Mast Cell Growth. 7. Mast Cell Apoptosis and its Regulation. SECTION II. 8. Early Signals in Mast Cell Activation: A Perspective. 9. FceRI- Signaling in specialized Membrane Domains. 10. Regulation of Function of Protein Tyrosine Kinase Syk in FceRI-mediated Signaling. 11. The Role of Protein Phosphatases in Cell Signaling by the High Affinity receptor for Immunoglobulin. 12. Protein Kinase C and Early Mast Cell Signals. 13. Mast Cell Inhibitory Receptors of the Immunoglobulin Superfamily. SECTION III. 14. Signaling Pathways that Regulate Effector Function-Perspectives. 15. Phosphoinositide-derived Second Messengers in FceRI- Signaling.