Synopses & Reviews
The genomes of humans, as well as many other species, are interspersed with hundreds of thousands of tandem repeats of DNA sequences.
Synopsis
This book details methods covering the analysis of tandem repeats in DNA, RNA and protein, in healthy and diseased states. It features step-by-step, readily reproducible laboratory protocols as well as lists of the necessary materials and reagents.
Table of Contents
1. Longitudinal Imaging and Analysis of Neurons Expressing Polyglutamine-Expanded Proteins Andrey S. Tsvetkov, D. Michael Ando & Steven Finkbeiner 2. Atomic Force Microscopy Assays for Evaluating Polyglutamine Aggregation in Solution and on Surfaces Kathleen A. Burke and Justin Legleiter 3. Morphometric Analysis of Huntington's Disease Neurodegeneration in Drosophila Wan Song, Marianne R. Smith, Adeela Syed, Tamas Lukacsovich, Brett A. Barbaro, Judith Purcell, Doug J. Bornemann, John Burke and J. Lawrence Marsh 4. Size Analysis of Polyglutamine Protein Aggregates using Fluorescence Detection in an Analytical UltracentrifugeSaskia Polling, Danny M. Hatters, and Yee-Foong Mok