Synopses & Reviews
Science is on the cusp of a revolutionary breakthrough. We now understand more about agingand how to prevent and reverse itthan ever before.
In recent years, our understanding of the nature of aging has grown exponentially, and dramatic life extensioneven age reversalhas moved from science fiction to real possibility.
Dr. Michael Fossel has been in the forefront of aging research for decades and is the author of the definitive textbook on human aging. In The Telomerase Revolution, he takes us on a detailed but highly accessible scientific journey, providing startling insights into the nature of human aging.
On first examination, aging appears inevitable and straight-forward. Everything, after all, from mountains and galaxies, to plants and animals, ages, doesnt it? Not exactly. With deeper consideration, aging turns out to be complex, and surprising questions emerge:
Is aging something that happens within our cells or in the organism as a whole?
Why do some cells age every time they reproduce, while others can reproduce indefinitely, without signs of aging?
How close are we to being able to dramatically extend life-spans and cure age-related diseases such as Alzheimers, dementia, and strokes?
Instead of the common idea that we accumulate damage, therefore we age,” the reality is the opposite: our cells age and so we begin to accumulate damage. The latest research shows so-called ageless” cells contain telomerase”an enzyme that maintains telomeres and adds back segments lost during replication. Essentially, it is the telomere that controls how well our cells repair themselves over time.
The Telomerase Revolution explains simply how we came to understand the ways aging and age-related diseases work, what we can do about them now, what we will be able to do to cure and prevent these diseasesand why we are now on the brink of a revolution in human medicine.
"The Telomerase Revolution
is a remarkable book, telling a fascinating story that pulls together at last a single coherent theory of how and why growing old leads to so many different forms of illness. It also offers a tantalizing promise that we might soon know not only how to cure and prevent age-related diseases, but how to reset the aging process itself. Michael Fossel is a radical optimist."
Matt Ridley, author of Genome and The Rational Optimist
"Telomerase Therapy breaks down centuries of human thought on aging and uproots outdated ideologies that have led to nothing but worthless snake oil products. Dr. Fossel's exciting book is opening doors to extended healthspan that can change human history, and its all grounded in solid scientific research."
Noel Patton, founder and chairman of TA Sciences
"Michael Fossels compelling argument for the telomere approach to reversing aging isnt just worth a lookits like reading the words of Virgil as he leads us along the mysteries of aging."
Alexey Olovnikov, PhD, Institute of Biochemical Physics and Russian Academy of Sciences
Aging is not an irreversible degenerative process, but an epigenetically determined physiological mechanism, which must not be confused with age-related diseases caused by lifestyle choices. Here, we have an effective and clear guide to understand how we get old and how to tame aging in a few years.”
Giacinto Libertini, MD, member of the Italian Society of Evolutionary Biology
"As a follow-up to his previous publications on the subject, Dr. Fossel brings the reader up-to-date on the progress made in understanding the central role of the telomere in aging. . . . Although a couple of decades of effort have ensued and candidate interventions have emerged, there are no strong and clinically proven interventions at the fore; however, Dr. Fossel constructs a very optimistic but realistic view of what may be on horizon to create the Telomerase Revolution."
Donald K. Ingram, PhD, professor at the Nutritional Neuroscience and Aging Laboratory, Pennington Biomedical Research Center
About the Author
Dr. Michael Fossel
earned both his PhD and MD from Stanford University, where he taught neurobiology and research methods. Winner of a National Science Foundation fellowship, he was a clinical professor of medicine for almost three decades, the executive director of the American Aging Association, and the founding editor of Rejuvenation Research
. In 1996, he wrote the first book on the telomerase theory of aging, Reversing Human Aging
, describing the medical aspects of extending human telomeres, reversing aging, and curing age-related disease. In 2004, he authored the magisterial academic textbook, Cells, Aging, and Human Disease
, and in 2011, he coauthored The Immortality Edge
, a bestselling discussion of the potential for extending the human lifespan. He currently teaches The Biology of Aging at Grand Valley State University.
The world's foremost expert on the clinical use of telomerase for age-related diseases, Michael has lectured at the National Institute for Health and the Smithsonian Institute, and continues to lecture at universities, institutes, and conferences throughout the world. He has appeared on Good Morning America, ABC 20/20, NBC Extra, Fox Network, CNN, BBC, Discovery Channel, and regularly on NPR. He is currently working to bring telomerase to human trials for Alzheimers disease.