Synopses & Reviews
Visit http://www.williamshematology.com for more information.
Williams HEMATOLOGY, 6th Edition, informs on new developments in genetics and molecular biology, sickle cell diseases, gene rearrangements, platelet morphology, biochemistry and function and so much more. Chapters remaining from the previous edition have been carefully reviewed and thoroughly updated, in order to provide you with the most current and authoritative coverage of the field now available.
The 6th Edition addresses the hottest topics in hematology today...
* New developments in the genetics and the molecular pathogenesis of blood cell disorders
* Extensive treatment of cytokine and chemokine networks in blood cell regulation
* The most recent diagnostic and treatment approaches to blood cell and coagulation protein disorders
* Advances in the management of the lymphomas and lymphocytic leukemias
* Comprehensive descriptions of the diagnosis and management of the cloncal myeloid diseases
* The most recent concepts of diseases of platelets and the management of hemostatic and thrombotic diseases
Visit http://www.williamshematology.com for more information.
Synopsis
A Doody's Core Title ESSENTIAL PURCHASE! After six editions, Williams Hematology remains the cornerstone text in the literature for hematology. Its discrete cell-by-cell approach has always been perceived as the most readily accessible by novices and experts alike, and now it is more clinical than ever through the inclusion of new key points boxes and algorithms that outline discrete strategies for diagnosis and treatment. There are also new chapters on the use of venous access devices, pain management, therapeutic use of cytokines, and flow cytometry. The latest moelcular biology techniques and 300 color plates enhance your diagnostic skills.
About the Author
Marshall Lichtman, M.D.Professor of MedicineUniversity of Rochester School of MedicineRochester, NYErnest Beutler, M.D.Professor and ChairmanDept. of Molecular Medicine and Experimental BiologyThe Scripps Research InstituteLa Jolla, CA
Table of Contents
Williams Hematology1 Approach to the patient2 Examination of the blood3 Examination of the marrow4 The marrow and hematopoietic microenvironment5 The lymphoid tissues6 Hematology of the newborn7 Hematology during pregnancy8 Hematology in the aged9 Genetic principles and molecular biology10 Cytogenetics and gene rearrangement11 Apoptosis12 Cell cycle regulation13 Signal transduction pathways14 The cluster of differentiation (CD) antigens15 Hematopoietic stem cells, progenitor cells, and cytokines16 The inflammatory response17 The innate immune system18 The adaptive immune system and dendritic cells19 Pharmacology and toxicity of antineoplastic drugs20 Treatment of infections in the immunocompromised host21 Principles of antithrombotic therapy22 Principles of hematopoietic stem cell transplantation23 Principles of immune cell therapy24 Principles of vaccine therapy25 Principles of therapeutic apheresis26 Principles of gene transfer for therapy27 Pain management28 Morphology of the erythron29 Composition of the erythrocyte30 Production of erythrocytes31 Destruction of erythrocytes32 Clinical manifestations and classification of erythrocyte disorders33 Aplastic anemia34 Pure red cell aplasia35 Anemia of chronic renal disease36 Anemia of endocrine disorders37 The congenital dyserythropoietic anemias38 Paroxysmal nocturnal hemoglobinuria39 Disorders of folic acid and cobalamin metabolism: the megaloblastic anemias40 Disorders of iron metabolism41 Anemia resulting from other nutritional deficiencies42 Anemia associated with marrow infiltration43 Anemia of chronic disease44 Disorders of the red cell membrane: hereditary spherocytosis, elliptocytosis, and related disorders45 Disorders of red cells resulting from enzyme abnormalities46 Disorders of globin synthesis: the thalassemias47 Disorders of hemoglobin structure: sickle cell anemia and related abnormalities48 Methemoglobinemia and other causes of cyanosis49 Hemolytic anemia resulting from physical injury to red cells50 Hemolytic anemia due to chemical and physical agents51 Hemolytic anemia due to infections with microorganisms52 Hemolytic anemia due to immune injury53 Alloimmune hemolytic disease of the newborn54 Acute blood loss anemia55 Hypersplenism and hyposplenism56 Primary and secondary polycythemia (Erythrocytosis)57 The hematologic aspects of porphyria58 Hereditary and acquired sideroblastic anemias59 Morphology of neutrophils, eosinophils, and basophils60 Composition of neutrophils61 Production, distribution, and fate of neutrophils62 Eosinophils and their disorders63 Basophils and mast cells, and their disorders64 Classification and clinical manifestations of neutrophil disorders65 Neutropenia and neutrophilia66 Disorders of neutrophil function67 Morphology of monocytes and macrophages68 Biochemistry and function of monocytes and macrophages69 Production, distribution, and fate of monocytes and macrophages70 Classification and clinical manifestations of disorders of monocytes and macrophages71 Monocytosis and monocytopenia72 Inflammatory and malignant histiocytosis73 Lipid storage diseases74 Morphology of lymphocytes and plasma cells75 Composition and biochemistry of lymphocytes and plasma cells76 Lymphopoiesis77 Functions of B lymphocytes and plasma cells in immunoglobin78 Functions of T lymphocytes: T-cell receptors for antigen79 Functions of natural killer cells80 Classification and clinical manifestations of lymphocytosis and plasma cell disorders81 Lymphocytosis and lymphocytopenia82 Immunodeficiency diseases83 Acquired immunodeficiency syndrome (AIDS)84 Mononucleosis syndromes85 Classification and clinical manifestations of the clonal myeloid disorders86 Myelodysplastic disorders (Clonal cytopenias and oligoblastic leukemia)87 Acute myelogenous leukemia88 Chronic myelogenous leukemia and related disorders89 Idiopathic myelofibrosis (agnogenic myeloid metaplasia)90 Classification of malignant lymphoid disorders91 Acute lymphocytic leukemia92 Chronic lymphocytic leukemia and related diseases93 Hairy cell leukemia94 Large granular lymphocytic leukemia95 Pathology of malignant lymphomas96 The non-Hodgkin lymphomas97 Hodgkin lymphoma98 Plasma cell neoplasms: General considerations99 Essential monoclonal gammopathies100 Plasma cell myeloma101 Amyloidosis102 Macroglobulinemia103 Heavy-chain disease104 Megakaryopoiesis and thrombopoiesis105 Platelet morphology, biochemistry and function106 Molecular biololgy and biochemistry of the coagulation factors and pathways of hemostasis107 Control of coagulation reactions108 Vascular function in hemostasis109 Classification, clinical manifestations and evaluation of disorders of hemostasis110 Thrombocytopenia111 Thrombocytosis and essential thrombocythemia112 Hereditary qualitative platelet disorders113 Acquired qualitative platelet disorders114 The vascular purpuras115 Hemophilia A and hemophilia B116 Inherited deficiencies of coagulation factors II, V, VII, XI and XIIIa117 Hereditary abnormalities of fibrinogen118 von Willebrand disease119 Antibody-mediated coagulation factor deficiencies120 Hemostatic dysfunction related to liver diseases and liver transplantation121 Disseminated intravascular coagulation122 Hereditary thrombophilias123 The antiphospholipid syndrome124 Antibody-mediated thrombotic disorders: thrombotic thrombocytopenia purpura and heparin induced thrombocytopenia125 Venous thrombosis126 Arterial thrombosis127 Fibrinolysis and thrombolysis128 Erythrocyte antigens and antibodies129 Human leukocyte and platelet antigens130 Blood procurement and screening131 Preservation and clinical use of erythrocytes and whole blood132 Preservation and clinical use of platelets