Synopses & Reviews
Molecular Toxicology reflects the revolution that toxicology has undergone in the last decade, as the molecular and genetic basis of the science--including drug metabolism, carcinogenesis, programmed cell death, and DNA repair--has been elucidated. It is the first text to explain the principles of toxicology in depth and from the perspective of modern biochemistry and molecular biology, while also providing a sense of the historical development of the science. Emphasizing the latest molecular biological approaches, the book covers xenobiotic biotransformation; reactive intermediates and their interactions with macromolecules; cloning, expression, and analysis of the enzymes of biotransformation; and molecular toxicology of aromatic amines, nitrosamines, polycyclic aromatic hydrocarbons, and chlorinated compounds. The toxicology of oxygen and oxidative stress is also covered in depth.
Extensively referenced, up-to-date, and rigorous, Molecular Toxicology is an ideal textbook for advanced undergraduate and graduate courses in molecular and biochemical toxicology, and also serves as a valuable resource for instructors and practicing scientists.
Table of Contents
Preface
Acknowledgments
1. Biochemical Background
2. Molecular Biology and Its Applications in Toxicology
3. Biological Oxidations
4. Superoxide and Superoxide Dismutase
5. Hydrogen Peroxide, Catalase, and Peroxidases
6. The Respiratory Burst
7. Lipid Peroxidation
8. Oxidative Stress in the Erythrocyte
9. Introduction to Xenobiotic Metabolism
10. Glucuronide Formation
11. Glutathione and Detoxication
12. Arylamine N-Acetyltransferase
13. Sulfotransferase
14. Cytochrome P-450
15. The AH Receptor and the Toxicity of Chlorinated Aromatic Compounds
16. Identification of DNA Adducts
17. Chemical Mutagenesis
18. Carcinogenesis: The Genetic Targets
19. Polycyclic Aromatic Hydrocarbon Carcinogenesis
20. Aromatic Amines and Other N-Aryl Compounds