Synopses & Reviews
Most "pathology" textbooks cover diseases and disease processes from the perspective of description (what does it look like and what are its characteristics), risk factors, disease-causing agents, and to some extent, cellular mechanisms. However, these books typically contain very sparse coverage (if any at all) of molecular mechanisms of disease. The reason for this is partially historical - most major forms of disease have been known for a long time, but the molecular basis of these diseases are not always known or have been elucidated only recently. Nevertheless, our overall understanding of the molecular and genetic mechanisms of the pathogenesis of most major human diseases has been advancing at a significant pace over the last two decades. As the molecular basis of human disease becomes better characterized, and the implications for understanding the molecular basis of disease becomes realized through improved diagnostics and treatment, there is a need for a new textbook where molecular mechanisms represent the focus.
Molecular Pathology focuses on the molecular basis of major human diseases and disease processes, presented in the context of traditional pathology, with implications for translational molecular medicine.
Molecular Pathology is appropriate as a classroom teaching tool for medical students, biomedical graduate students, and some allied health students. In addition, it should be used as a reference book for practicing basic scientists and physician scientists that perform disease-related research. Further, this textbook will be valuable for pathology residents and other postdoctoral fellows who need to advance their understanding of molecular mechanisms of disease beyond what they learned in medical/graduate school.
* Exam Master® web site will host "Self-assessment" questions that students can use to study for the molecular section of the board exam
* Companion Web Site – would host a complete set of PowerPoint slides: to include images from the book and additional images for teaching; course materials; lecture materials
* Teaches from the perspective of “integrative systems biology,” which encompasses the intersection of all molecular aspects of biology, as applied to understanding human disease
* Outlines the principles and practice of molecular pathology: molecular pathogenesis, molecular mechanisms of disease, and how the molecular pathogenesis of disease parallels the evolution of the disease using histopathology
* Explains the practice of “molecular medicine” and the translational aspects of molecular pathology: molecular diagnostics, molecular assessment, and personalized medicine
Synopsis
Molecular Pathology: The Molecular Basis of Human Disease provides a current and comprehensive view of the molecular basis and mechanisms of human disease. Combining accepted principles with broader theoretical concepts and with contributions from a group of experts, the book looks into disease processes in the context of traditional pathology and their implications for translational molecular medicine. It also discusses concepts in molecular biology and genetics, recent scientific and technological advances in modern pathology, the concept of ""molecular pathogenesis"" of disease, and how disease evolves from normal cells and tissues due to perturbations in molecular pathways.
The book describes the integration of molecular and cellular pathogenesis using a bioinformatics approach and a systems biology approach to disease pathogenesis. It also discusses current and future strategies in molecular diagnosis of human disease, and the impact of molecular diagnosis on treatment decisions and the practice of personalized medicine.
This book is a valuable resource for students, biomedical researchers, practicing physician-scientists who undertake disease-related basic science and translational research, and pathology residents and other postdoctoral fellows.
- Exam Master(R) web site will host "Self-assessment" questions that students can use to study for the molecular section of the board exam
- Teaches from the perspective of "integrative systems biology," which encompasses the intersection of all molecular aspects of biology, as applied to understanding human disease
- Outlines the principles and practice of molecular pathology
- Explains the practice of "molecular medicine" and the translational aspects of molecular pathology
Synopsis
Medical textbook that offers uniquely broad coverage of the molecular basis of major human diseases in the context of traditional pathology, with implications for translational molecular medicine.
Synopsis
"The editors of
Molecular Pathology have produced a comprehensive compendium of the state-of-the-art in molecular pathogenesis, an impressive accomplishment given the diverse cells and organ systems involved in human disease. An established cadre of experts has contributed to this first, well-designed edition. As a result, essential topics ranging from cell injury/death, the molecular basis of cardiovascular diseases and disorders of the nervous system, and modern molecular diagnostics are amply addressed. In a rapidly emerging discipline, it is challenging to capture the details that define the field. Molecular Pathology has accomplished this goal in an outstanding manner and will serve as an excellent resource for those already established in clinical care and biomedical research, for those who seek to maintain competency in molecular pathology, as well as for all students involved in interdisciplinary studies related to human disease or modern clinical investigations."
--Linda M. McManus, PhD, Professor, University of Texas Health Science Center at San Antonio
"The focus of Molecular Pathology is genetic and molecular but it has been written to enhance the work of an active pathologist, clearly describing the basics as well as providing ample sampling of the molecular complexities of disease. Gladly the editors did not assemble an exhaustive compendium of facts and details that would inevitably become obsolete in short order. Instead, the contributors concentrated on clarity of explanation supported by selected examples so that the reader may grasp the fundamentals better. In fact, this may be one medical textbook that can be read cover-to-cover without being lost in details. The figures are clear, helpful, and plentiful which is important when dealing with so many complex technologies and concepts. I highly recommend this book."
--Edison T. Liu, M.D, Executive Director, Genome Institute of Singapore
About the Author
Dr. William B. Coleman is Professor of Pathology and Laboratory Medicine and Director of Graduate Studies for the Molecular and Cellular Pathology Graduate Program at the University of North Carolina School of Medicine (Chapel Hill, NC). Dr. Coleman is co-director of the UNC Program in Translational Medicine, and co-director of the Environmental Pathology Predoctoral and Postdoctoral Training Program. In addition, he is affiliated with the Curriculum in Toxicology and is a member of the UNC Lineberger Comprehensive Cancer Center. Dr. Coleman is actively involved in teaching biomedical graduate students and is a three-time recipient of the Joe W. Grisham Award for Excellence in Graduate Student Teaching from the Molecular and Cellular Pathology graduate students at UNC-Chapel Hill. Dr. Coleman is active in the leadership of the American Society for Investigative Pathology, and is a member of the American Association for Cancer Research. He serves on the editorial boards of Clinica Chimica Acta, The American Journal of Pathology, Experimental and Molecular Pathology, Archives of Pathology and Laboratory Medicine, and Laboratory Investigation, and has served as an ad hoc reviewer for 48 other journals. Dr. Coleman’s major research interests are in the molecular pathogenesis of human cancers, with a specific interest in breast cancer epigenetics, liver carcinogenesis, and lung cancer biology. His research has been funded by the NIH/NCI, The Susan G. Komen Breast Cancer Foundation, Friends for an Earlier Breast Cancer Test, and the UNC Lineberger Comprehensive Cancer Center. Dr. Coleman is the author of over 100 original research articles, reviews, and book chapters. In addition, Dr. Coleman has co-edited or co-authored six books on topics related to molecular pathology, molecular diagnostics, and the molecular pathogenesis of human cancer.
Associate Professor, Department of Pathology, Dartmouth Medical School and Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
Table of Contents
PART I: Essential Pathology - Mechanisms of DiseaseMolecular Mechanisms of Cell Death
Acute and Chronic Inflammation
Infection and Host Response
Neoplasia
PART II: Concepts in Molecular Biology and Genetics
Basic Concepts in Human Molecular Genetics
The Human Genome: Implications for the Understanding of Human Disease
The Human Transcriptome: Implications for the Understanding of Human Disease
The Human Epigenome: Implications for the Understanding of Human Disease
The Human Proteome: Implications for the Understanding of Human Disease
Integrative Systems Biology: Implications for the Understanding of Human Disease
PART III:Principles and Practice of Molecular Pathology
Pathology: The Clinical Description of Human Disease
Molecular Pathogenesis: The Biological Basis of Human Disease
Integration of Molecular and Cellular Pathogenesis
PART IV: Molecular Pathology of Human Disease
Molecular Basis of Cardiovascular Disease
Molecular Basis of Hemostatic and Thrombotic Diseases
Molecular Basis of Lymphoid and Myeloid Diseases
Molecular Basis of Diseases of Immunity
Molecular Basis of Pulmonary Disease
Molecular Basis of Diseases of the Gastrointestinal Tract
Molecular Basis of Liver Disease
Molecular Basis of Diseases of the Exocrine Pancreas
Molecular Basis of Diseases of the Endocrine System
Molecular Basis of Gynecologic Diseases
Molecular Basis of Prostate Disease
Molecular Basis of Breast Disease
Molecular Basis of Skin Disease
Molecular Basis of Diseases of the Nervous System
PART V: Practice of Molecular Medicine
Molecular Diagnosis of Human Disease
Molecular Assessment of Human Disease in the Clinical Laboratory
Pharmacogenomics and Personalized Medicine in the Treatment of Human Disease