Synopses & Reviews
Synopsis
This book summarizes early pioneering achievements in the field of human neural stem cell (hNSC) research and combines them with the latest advances in stem cell technology, including reprogramming and gene editing. The powerful potential of hNSC to generate and repair the developing and adult CNS has been confirmed by numerous experimental in vitro and in vivo studies. The book presents methods for hNSC derivation and discusses the mechanisms underlying NSC in vitro fate decisions and their in vivo therapeutic mode of action.
The long-standing dogma that the human central nervous system (CNS) lacks the ability to regenerate was refuted at the end of the 20th century, when evidence of the presence of neurogenic zones in the adult human brain was found. These neurogenic zones are home to human neural stem cells (hNSCs), which are capable of self-renewing and differentiating into neurons, astrocytes and oligodendrocytes. NSCs isolated from human CNS have a number of clinical advantages, especially the innate potential to differentiate into functional neural cells. Nevertheless, their full clinical exploitation has been hindered by limited access to the tissue and low expansion potential. The search for an alternative to CNS sources of autologous, therapeutically competent hNSCs was the driving force for the many studies proving the in vitro plasticity of different somatic stem cells to generate NSCs and their functional progeny. Now the era of induced pluripotent stem cells has opened entirely new opportunities to achieve research and therapeutic goals with the aid of hNSCs.
Synopsis
I. Derivation and/or generation of human neural stem cells1. Derivation of neural stem cells from the developing and adult human brain. Maeve Caldwell
[email protected] 2. Generation of neural stem cells from human after-birth tissues. David Eve
[email protected], Poul Sanberg
[email protected], Krystyna Domanska-Janik
[email protected], Leonora Buzanska
[email protected] 3. Derivation of neural stem cells from human somatic tissues. Anna Sarnowska
[email protected], Anna Dąbrowska-Figiel
[email protected]. Generation of human neural stem cells from induced pluripotent stem cells. Eva Sykova
[email protected], Pavela Jendelova
[email protected] 5. Generation of human neural stem cells by direct phenotypic conversion. Kyung-Sun Kang
[email protected] II. Differentiation and underlying mechanisms6. Epigenetic regulation of human neural stem cell differentiation. Kinichi Nakashima [email protected], Sayako Katada [email protected], Mizuki [email protected]. Integrated genome regulation in human neural stem cells. Stachowiak MK [email protected]
8. Human neural stem cells and glial specification. Milosz Pekny. [email protected]
9. Differentiation of human pluripotent stem cells into motor neurons. Ping Wu, [email protected]
10. Microenvironmental cues in human neural stem cell fate commitment. Leonora Buzanska [email protected], Marzena Zychowicz [email protected]
11. Generation of human fetal region specific NSC by CRISP/COS genome editing. Steven Pollard [email protected]
12. Generation of region specific human brain organoids. Hongjung Song, [email protected]
III. Therapeutic potential of Human neural stem cells13. Functional Multipotency of hNSCs and Its Applications in Spinal Cord Injury Research and Treatment. Yang D. Teng [email protected]
14. Human neural stem cells for ischemic stroke treatment. Zaal Kokaia [email protected]
15. Modeling pediatric and neuropsychiatric diseases using human iPSC. Evan Snyder [email protected]
16. Neural stem cell dysfunction in human brain diseases. Jacek Jaworski [email protected], Ewa Liszewska [email protected]
17. Human neural stem cells for neurodegenerative diseases treatment. Angelo Vescovi [email protected]
Synopsis
Summarizes the most recent advances in human neural stem cells (hNSC) research
Presents hNSC derivation methods
Discusses mechanisms underlying NSC in vitro fate decisions and their in vivo therapeutic mode of action
Outlines therapeutic potential of human neural stem cells