Store-Operated Ca2+ Entry (Soce) Pathways: Emerging Signaling Concepts in Human (Patho)Physiology

Store-operated Ca2+ entry (SOCE) serves to control essential functions throughout the human body and represents a novel and attractive target for therapeutic intervention. This book provides an extensive overview of the role of SOCE pathways in Molecular Physiology and Cell Biology, as well as their clinical significance. (Patho)physiological principles and emerging therapeutic strategies are delineated in a way that is valuable both for the education of graduate students in advanced Cell Biology/Molecular Physiology and for the promotion of innovative research and developments in the clinical/therapeutic fields. A comprehensive, clear and elaborate representation of current concepts is provided, including a pathophysiological section arranged in a tissue/organ/system-oriented manner. The book is intended for basic researchers specializing in cell signaling, ion transport, or pharmacology, as well as biomedical scientists and clinicians with a focus on immunology, neurology or cardiology.

This book thoroughly explores robotics in neurorehabilitative therapy, describing state-of-the-art applications of robotic devices for locomotion; posture and balance and upper extremity recovery in stroke. Includes schematic diagrams, photographs and tables.

Prof. Klaus Groschner studied Pharmacy at the School of Pharmacy, University of Graz, Austria. He completed his PhD studies at the Department of Pharmacodynamics in Graz and received part of his postdoctoral education at the University of Miami, Florida, USA, studying electrophysiology and cell biology. In 1990 he became an Assistant Professor at the Department of Pharmacology and Toxicology and in 1993, he became an Professor in Pharmacology and Toxicology (Habilitation) at the University of Graz. He is currently head of the research group for the physiology and pathophysiology of membrane transport and an Associate Professor at the Institute for Pharmaceutical Sciences, University of Graz. Prof. Wolfgang F.

Preface (C. Romanin, W. F. Graier, K. Groschner).- SECTION 1: SOCE - Fundamental mechanistic concepts.- Introduction (J. W. Putney).- 1.1 The STIM-Orai pathway.- Structural insights into Ca2+ sensing by stromal interaction molecules (P. B. Stathopulos, M. Ikura).- 1.2 The STIM-Orai pathway. Orai, the pore-forming subunit of the CRAC channel (P. G. Hogan).- 1.3 The STIM-Orai pathway. The interactions between STIM and Orai (R. Schindl, M. Fahrner, M. Muik, I. Derler, C. Romanin).- 1.4 STIM-TRP pathways. The STIM1/Orai/TRPC channels multiple Ca2+ influx complexes (J. H. Hong, M. S. Kim, K. P. Lee, J. P. Yuan, S. Muallem).- 1.5 STIM-TRP pathways. Function and regulation of TRPC1: Contribution to Ca2+ entry activated by store depletion (I. S. Ambudkar, K. T. Cheng, H. L. Ong, X. Liu).- 1.6 Microdomain organization and the role of second messengers. Microdomain organization of SOCE signaling (C. Moreno, L. Vaca).- 1.7 Microdomain organization and the role of second messengers. Store-operated Ca2+ entry: Endogenous messengers and mediators (V. M. Bolotina).- SECTION 2: SOCE - Crosstalk between organelle and cellular compartments.- Introduction: Ca2+ signaling and gene regulation: An introduction (A. B. Parekh).- 2.1 New aspects of the contribution of ER to SOCE regulation. The role of the ER and ER-plasma membrane junctions in the regulation of SOCE (H. Dingsdale, L. Haynes, G. Lur, A. Tepikin).- 2.2 New aspects of the contribution of ER to SOCE regulation. The contribution of SERCA to the regulation of SOCE (J. García-Sancho, M. T. Alonso).- 2.3 New aspects of the contribution of ER to SOCE regulation. TRPC proteins as a link between plasma membrane ion transport and intracellular Ca2+ stores (A. Bavencoffe, M. X. Zhu).- 2.4 The role of mitochondria in the activation/maintenance of SOCE. Store-operated Ca2+ entry and mitochondria (A. Spät, G. Szanda).- 2.5 The role of mitochondria in the activation/maintenance of SOCE. Local regulation of plasma membrane channels by mitochondria (N. Demaurex, M. Frieden).- 2.6 The role of mitochondria in the activation/maintenance of SOCE. The contribution of distinct mitochondrial Ca2+ uptake mechanisms, mitochondrial motility and location to store-operated Ca2+ entry (R. Malli, W. F. Graier).- 2.7 Tissue specificity. The role of nanospaces between the organellar membranes in smooth muscle Ca2+ signaling (N. Fameli, A. M. Evans, C. van Breemen).- 2.8 Tissue specificity. SOCE - implications for Ca2+ handling in endothelial cells (L. A. Blatter).- SECTION 3: SOCE - Molecular and cellular (patho)physiology.- Introduction (J. A. Rosado).- 3.1 Immune system. SOCE mediated by STIM and Orai genes in immune function and disease (S. Feske).- 3.2: Cardiovascular system. STIM1/Orai1-mediated store-operated Ca2+ entry in cardiovascular disease (R. K. Motiani, M. Trebak).- 3.3: Cardiovascular system. TRPC/Orai-containing channels, Na+/Ca2+ + exchanger and Ca2+ handling in hypertension (V. A. Golovina).- 3.4: Cardiovascular system. SOCE and TRPC/STIM/Orai signaling in cardiac myocytes (H. Watanabe, T. Ohba, H. Ito).- 3.5: Cardiovascular system. SOCE as a determinant of cardiac pacemaker activity (D.G. Allen, Y. K. Ju, J. Liu, M. S. Imtiaz).- 3.6: Cardiovascular system. SOCE and Ca2+ handling in platelet dysfunction (J. J. Lopez, G. M. Salido, J. A. Rosado).- 3.7: Cardiovascular system. Store-operated Ca2+ entry in endothelial pathophysiology (K. Groschner, M. Poteser).- 3.8: Nervous system. Pathophysiological perspective of neuronal store-operated Ca2+ signaling (S. Bollimuntha, B. Pani, B. B. Singh).- 3.9: Skeletal muscle. Store-operated Ca2+ entry and STIM/Orai signaling in skeletal muscle (J. A. Stiber, P. B. Rosenberg).- 3.10: Skeletal muscle. Store-operated channels and Ca2+ handling in muscular dystrophy (U. T. Ruegg, G. Shapovalov, K. Jacobson, J. Reutenauer-Patte, H. Ismail, O. M. Dorchies, P. Avdonin).- 3.11: Reproductive system. Store-operated Ca2+ entry in germ cells - role in egg activation (Z. Machaty, C. Wang, K. Lee).