Synopses & Reviews
Treated here are electrogenic Cl- transport processes and their interaction with metabolic or ionic flows in representative plasma membranes of all living beings. Leading experts cover the following topics in short reviews: Photon and ATP-driven Cl- transporters, proton-driven Cl- symporters, sulfate-driven Cl- antiporters, Cl- channels in unicellular and multicellular organisms ranging from bacteria and protozoa to higher mammals. Regulation of these mechanisms either directly or through secondary messengers or via nuclear commands are also discussed. The book also elucidates the wide spectrum of new methods (e.g. patch clamping, reconstitution, molecular biology, etc.) now available for the application to various cellular plasma membrane systems, and demonstrates that certain cellular systems from simple organisms may serve as paradigms for other cellular membrane processes from more complex organisms.
Biological cell membranes regulate the transfer of matter and informa tion between the intracellular and extracellular compartments as basic survival and maintenance functions for an organism: This volume contains a series of reviews that are concerned with how biological plasma membranes regulate the transport of chloride between the intracellular and extracellular compartments of a cell. This book is also an attempt to analyze the molecular basis for the movement of chloride across a cell membrane. This volume is devoted to a diversity of electrogenic chloride transport mechanisms in representative cell membranes of all living things. The first section of the book (Chaps. 1-4) focuses on mech anisms of primary active chloride transport (i.e. photon or A TP-driven), while the second section (Chaps. 5-6) centers on secondary active chloride transporters (symport and antiport) in both plant and animal plasma membranes. The last section, which comprises seven chapters (Chaps. 7-13), deals with chloride channels in cell membranes of prokaryocytes and eukaryocytes of most every phylum. It is hoped that with this particular ordering the reader can glean a telescopic view of the evolutionary history of the various electrogenic chloride transporters."