Synopses & Reviews
This volume provides new insight into the histogenesis of bone tumors, in particular fibrohistiocytic tumors, chondromas, and chondroid chordomas. The potential of various techniques - immunohistology, flow cytometry - for improved classification and differential diagnosis is discussed. In particular, Ewing's sarcoma and other round cell sarcomas of bone are treated. Methods for determining proliferation behavior are included; and new data on the role of bone-specific proteins is presented for the first time.
During the past few years, a considerable number of monographs on bone tumors have been published. They are mainly restricted to bone tumors as clinical-pathological entities, since their diagnosis, more than that of other tumors, requires the interdisciplinary cooperation between orthopedic specialist, radiologist, and pathologist. However, investiga- tions concerning the histogenesis of bone tumors are rather limited, although they might be helpful in explaining the unique morphological heterogeneity of tumors of the skeletal system. Furthermore, the histo- genetic approach in the study of bone tumors may facilitate the inter- pretation of the advanced cytobiological methods available for improv- ing classification and diagnosis. Therefore, this volume presents recent pathological advances in the biological characterization of bone tumors. A major chapter deals with the differential diagnosis of Ewing's sarcoma as regards its demarcation from the so-called neuroectodermal tumor of bone. The analysis of the ground substances in bone-forming tumors may be helpful for their classification. Therefore the volume includes a chapter on the biochemical and histochemical analysis of different osteosarcoma types. Recently it has become clear that in addition to different collagen types which are not specific for bone tissue, several bone-specific proteins occur, one of which is osteonectin. Its distribu- tion is obviously important for the classification and diagnosis of osteo- blastic tumors. Proliferative behavior is of major importance for the diagnosis of malignant tumors.