Bone Densitometry and Osteoporosis

The purpose of this book is to provide a perspective on the current status of bone densitometry and its relevance to osteoporosis diagnosis and management. Therefore, this book will give the reader an introduction to the nature of osteoporosis, its pathophysiology and epidemiology, and the clinical consequences of performing bone densitometry. Aside from standard bone densitometry, newer technologies such as quantitative ultrasound techniques, magnetic resonance imaging and bone structure analysis are discussed in the context of diagnosing osteoporosis.

The diagnosis of osteoporosis and the determination of fracture risk has always been a challenge for radiologists, epidemiologists, and clinicians as well as oth- er researchers and health care professionals working in the field. It is bone min- eral density that is closely related to bone fragility, and the advent of techniques to quantitatively assess bone density has been welcomed. It has reduced the sub- jectivity inherent to conventional radiologic assessment of osteoporosis. The on- going technical process has made various techJ)iques to assess bone density wide- ly available. However, these measurement techniques have also incurred some crit- icism because bone densitometry has sometimes been applied without specific indications and without appropriate clinical ramifications. The purpose of this text is to provide a perspective on the current status of bone densitometry and ist relevance to osteoporosis diagnosis and management. Therefore, this book will give the reader an introduction to the nature of osteo- porosis, its pathophysiology and epidemiology, and the clinical consequences of performing bone densitometry. Aside from standard bone densitometry, newer technologies such as quantitative ultrasound techniques, magnetic resonance imaging and bone structure analysis are discussed in the context of diagnosing osteoporosis.

From the contents: Osteoporosis: The Clinical Problem.- Epidemiology of Osteoporosis.- The Physiology of Bone Turnover.- Growth Factors and the Skeleton.- Cellular Basis of Bone Resorption.- Biochemical Markers of Bone Turnover.- Determinants of Bone Loss.- Biomechanical Properties of Bone.- Risk Factors for Osteoporosis Fractures.- Bone Biopsy in Metabolic Bone Disease.- Basic Considerations and Definitions in Bone Densitometry.- Radiology of Osteoporosis.- Assessment of Vertebral Fracture.- Osteoporosis and Oral Bone Loss.