Synopses & Reviews
Carbohydrates in Drug Discovery and Development: Synthesis and Applications
examines recent, important developments in synthesis, biology, and biomedical applications of carbohydrates as well as therapeutic and pharmacological aspects of carbohydrate chemistry. Structural aspects of carbohydrates make this moiety efficiently able to form diverse linkages, substitutions, and branching patterns which have attracted generations of chemists towards harnessing these properties. In addition to the advancement in construction of oligosaccharides, chemists are also making strides in the ability to assemble glycopeptides and glycoproteins. These are important synthetic targets, not only from a basic research standpoint but also because they play essential biological roles. Carbohydrates are one of the most challenging classes of biomolecules in terms of synthesis, structure, and biological implications. This book covers advanced aspects of carbohydrates, starting with a brief introduction, nomenclature, and classification, followed by a discussion of glycosidic bond formation methodology, recent protocols for the synthesis of O-glycosides, N-glycosides, thioglycosides and C-glycosides, Intramolecular Aglycon Delivery (IAD), carbohydrate modification, as well as standard protection-deprotection techniques in carbohydrate chemistry. Written by a team of international experts actively working on different aspect of synthetic carbohydrate chemistry, this book is an invaluable resource for carbohydrate chemists, natural products chemists, medicinal chemists, synthetic organic chemists and biochemists working in industry and academia.
- Gives a practical, detailed overview of a wide range of carbohydrate systems relevant for drug discovery and development
- Highlights applications of functionalized carbohydrates and their use as synthons for the construction of various systems
- Covers recent developments in the synthesis of various glycohybrid molecules
Carbohydrates in Drug Discovery and Development: Synthesis and Applications examines recent and notable developments in the synthesis, biology, therapeutic, and biomedical applications of carbohydrates, which is considered to be a highly promising area of research in the field of medicinal chemistry. Their role in several important biological processes, notably energy storage, transport, modulation of protein function, intercellular adhesion, malignant transformation, signal transduction, viral, and bacterial cell surface recognition formulate the carbohydrate systems to be an exceedingly considerable scaffold for the development of new chemical entities of pharmacological importance. In addition to their easy accessibility, high functionality and chiralpool characteristics are the few additional fascinating structural features of carbohydrates, which further enhance their utilities and thus they have been able to attract chemists and biologists toward harnessing these properties for the past several decades.
This book covers an advanced aspect of carbohydrate-based molecular scaffolding, starting with a general introduction followed by a detailed discussion about the impact of diverse carbohydrate-containing molecules of great therapeutic values and their impact on drug discovery and development. The topics covered in this book include the significance of heparin mimetics as the possible tools for the modulation of biology and therapy, chemistry and bioactivities of C-glycosylated compounds, inositols, iminosugars, KDO, sialic acids, glycohybrids, macrocycles, plant oligosaccharides, anti-bacterial and anti-cancer vaccines, antibiotics, and more.