Synopses & Reviews
Rapid advances in computer science, biology, chemistry, and other disciplines are enabling powerful new computational tools and models for toxicology and pharmacology. These computational tools hold tremendous promise for advancing applied and basic science, from streamlining drug efficacy and safety testing, to increasing the efficiency and effectiveness of risk assessment for environmental chemicals. Computational Toxicology was conceived to provide both experienced and new biomedical and quantitative scientists with essential background, context, examples, useful tips, and an overview of current developments in the field. This two-volume set serves as a resource to help introduce and guide readers in the development and practice of these tools to solve problems and perform analyses in this area. Divided into six sections, Volume II covers a wide array of methodologies and topics. The volume begins by exploring the critical area of predicting toxicological and pharmacological endpoints, as well as approaches used in the analysis of gene, signaling, regulatory, and metabolic networks. The next section focuses on diagnostic and prognostic molecular indicators (biomarkers), followed by the application of modeling in the context of government regulatory agencies.
Synopsis
This resource features essential background, context, examples, useful tips, and an overview of current developments in the field. It includes cutting-edge methods and protocols as well as implementation advice from the experts.
Synopsis
Part 1. Toxicological/Pharmacological Endpoint Prediction
1. Methods for Building QSARs
James Devillers
2. Accessing and Using Chemical Databases
Nikolai Nikolov, Todor Pavlov, Jay R. Niemel , and Ovanes Mekenyan
3. From QSAR to QSIIR: Searching for Enhanced Computational Toxicology Models
Hao Zhu
4. Mutagenicity, Carcinogenicity and Other Endpoints
Romualdo Benigni, Chiara Laura Battistelli, Cecilia Bossa, Mauro Colafranceschi, and Olga Tcheremenskaia
5. Classification Models for Safe Drug Molecules
A.K. Madan, Sanjay Bajaj, and Harish Dureja
6. QSAR and Metabolic Assessment Tools in the Assessment of Genotoxicity
Andrew P. Worth, Silvia Lapenna, and Rositsa Serafimova
Part II. Biological Network Modeling
7. Gene Expression Networks
Reuben Thomas and Christopher J. Portier
8. Construction of Cell Type-Specific Logic Models of Signaling Networks Using CellNetOptimizer
Melody K. Morris, Ioannis Melas, and Julio Saez-Rodriguez
9. Regulatory Networks
Gilles Bernot, Jean-Paul Comet, and Christine Risso- de Faverney
10. Computational Reconstruction of Metabolic Networks from KEGG
Tingting Zhou
Part III. Biomarkers
11. Biomarkers
Harmony Larson, Elena Chan, Sucha Sudarsanam, and Dale E. Johnson
12. Biomarkers: Environmental Public Health Indicators
Andrey I. Egorov, Dafina Dalbokova, and Michal Kryzanowski
Part IV. Modeling for Regulatory Purposes (Risk and Safety Assessment)
13. Modeling for Regulatory Purposes (Risk and Safety Assessment)
Hisham El-Masri
14. Developmental Toxicity Prediction
Raghuraman Venkatapathy and Nina Ching Y. Wang
15. Predictive Computational Toxicology to Support Drug Safety Assessment
Luis G. Valerio, Jr.
Part V. Integrated Modeling/Systems Toxicology Approaches
16. Developing a Practical Toxicogenomics Data Analysis System Utilizing Open-Source Software
Takehiro Hirai and Naoki Kiyosawa
17. Systems Toxicology from Genes to Organs
John Jack, John Wambaugh, and Imran Shah
18. Agent Based Models of Cellular Systems
Nicola Cannata, Flavio Corradini, Emanuela Merelli, and Luca Tesei
Part VI. Mathematical and Statistical Background
19. Linear Algebra
Kenneth Kuttler
20. Ordinary Differential Equations
Jiř Lebl
21. On the Development and Validation of QSAR Models
Paola Gramatica
22. Principal Components Analysis
Detlef Groth, Stefanie Hartmann, Sebastian Klie, and Joachim Selbig
23. Partial Least Square Methods: Partial Least Squares Correlation and Partial Least Square Regression
Herv Abdi and Lynne J. Williams
24. Maximum Likelihood
Shuying Yang and Daniela De Angelis
25. Bayesian Inference
Fr d ric Y. Bois
Table of Contents
Part 1. Toxicological/Pharmacological Endpoint Prediction 1. Methods for Building QSARs James Devillers 2. Accessing and Using Chemical Databases Nikolai Nikolov, Todor Pavlov, Jay R. Niemelä, and Ovanes Mekenyan 3. From QSAR to QSIIR: Searching for Enhanced Computational Toxicology Models Hao Zhu 4. Mutagenicity, Carcinogenicity and Other Endpoints Romualdo Benigni, Chiara Laura Battistelli, Cecilia Bossa, Mauro Colafranceschi, and Olga Tcheremenskaia 5. Classification Models for Safe Drug Molecules A.K. Madan, Sanjay Bajaj, and Harish Dureja 6. QSAR and Metabolic Assessment Tools in the Assessment of Genotoxicity Andrew P. Worth, Silvia Lapenna, and Rositsa Serafimova Part II. Biological Network Modeling 7. Gene Expression Networks Reuben Thomas and Christopher J. Portier 8. Construction of Cell Type-Specific Logic Models of Signaling Networks Using CellNetOptimizer Melody K. Morris, Ioannis Melas, and Julio Saez-Rodriguez 9. Regulatory Networks Gilles Bernot, Jean-Paul Comet, and Christine Risso- de Faverney 10. Computational Reconstruction of Metabolic Networks from KEGG Tingting Zhou Part III. Biomarkers 11. Biomarkers Harmony Larson, Elena Chan, Sucha Sudarsanam, and Dale E. Johnson 12. Biomarkers: Environmental Public Health Indicators Andrey I. Egorov, Dafina Dalbokova, and Michal Kryzanowski Part IV. Modeling for Regulatory Purposes (Risk and Safety Assessment) 13. Modeling for Regulatory Purposes (Risk and Safety Assessment) Hisham El-Masri 14. Developmental Toxicity Prediction Raghuraman Venkatapathy and Nina Ching Y. Wang 15. Predictive Computational Toxicology to Support Drug Safety Assessment Luis G. Valerio, Jr. Part V. Integrated Modeling/Systems Toxicology Approaches 16. Developing a Practical Toxicogenomics Data Analysis System Utilizing Open-Source Software Takehiro Hirai and Naoki Kiyosawa 17. Systems Toxicology from Genes to Organs John Jack, John Wambaugh, and Imran Shah 18. Agent Based Models of Cellular Systems Nicola Cannata, Flavio Corradini, Emanuela Merelli, and Luca Tesei Part VI. Mathematical and Statistical Background 19. Linear Algebra Kenneth Kuttler 20. Ordinary Differential Equations Jiří Lebl 21. On the Development and Validation of QSAR Models Paola Gramatica 22. Principal Components Analysis Detlef Groth, Stefanie Hartmann, Sebastian Klie, and Joachim Selbig 23. Partial Least Square Methods: Partial Least Squares Correlation and Partial Least Square Regression Hervé Abdi and Lynne J. Williams 24. Maximum Likelihood Shuying Yang and Daniela De Angelis 25. Bayesian Inference Frédéric Y. Bois