Synopses & Reviews
Synopsis
Excerpt from Creatine Metabolism: A Dissertation Submitted to the Faculty of the Graduate College of the State University of Iowa, in Partial Fullfillment of the Requirements for the Degree of Doctor of Philosophy
At the beginning of this investigation it was planned to study the relationship of creatine metabolism to the methyl guanidine content of normal tissues and the occurrence of this body in the urine and blood in conditions of parathyroid insufficiency in animals. An investigation of the methods, used to determine methyl guanidine in the presence of creatine or creatinine in tissue extracts, blood, and urine by previous investigators, has convinced the author that these methods are unsuitable for any analytical investigation. Work on this problem has been post poned until more reliable methods are available. For the determi nation Of guanidine compounds. An investigation has been made of the possibility that a relationship exists between creatine and carbohydrate metabolism, analogous to the ketogenic and anti ketogenic balance, existing in the oxidation of fat and carbo hydrate. The effect of variations in the amount of fat and carbohydrate in the diets upon the creatine has been studied in two cases of well established creatinuria. The effect of glucose upon the oxidation of creatine by hydrogen peroxide has been observed. A study of the effect of the addition of pancreas ex tract to autolyzing muscle on the sugar content and the creatine creatinine balance has been made. The effect of kidney extract has been compared to muscle extract in its ability to convert creatine to creatinine in vitro.
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