Growth Hormone and Somatomedins During Lifespan

This book provides an excellent and critical update of the present knowledgeon the action and function of growth hormone and insuline-like growth factors as well as the potential uses of the hormone and its dependent peptides in an increasing number of physiological and pathological conditions. It is of primary interest to basic and clinical endocrinologists, neuroendocrinologists, pediatric endocrinologists, gynecologists and gerontologists.

The various congresses on growth hormone (GH) which have been held in Milan since 1967, the Milan Congresses, have witnessed over 25 years the tremendous expansion of a research field that was based initially upon the scarce knowledge of the biological properties of a protein. GH, whose chemical structure had just been identified and a radioimmunoassay developed for its measurement in blood, became in the following years a major area of biological research. The boundaries have since become blurred, as the research area has extended to the physiology and pathology of growth, puberty and reproduction, and the control of metabolism during the whole lifespan. Since the last GH Congress held in 1987, GH studies using the molecular biological approach have resulted in the puri fication, cloning and expression of the human GH (hGH) recep tor and binding protein, in new and exciting information on the insulin-like growth factors (IGF) and their paracrine and autocrine roles, and in the awareness that a panoply of binding proteins are present in the extracellular fluids and can, possibly, modulate IGF-receptor interactions and, thus, IGF actions. Finally, the availability of large amounts of biosynthetic hGH, besides allow ing more extensive clinical use in states of GH deficiency and extrasomatotrophic pathologies, has permitted disclosure of im portant metabolic effects of hGH during adulthood and, perhaps, aging and in many protein catabolic states."

From the contents: Growth Hormones.- Somatomedins.- Fetal and Neonatal Growth.- Pubertal Development.- Adulthood and Senescence.