Synopses & Reviews
Books on both chicken immunology and developmental biology are rare. This one, however, summarizes all aspects of both areas and therefore represents a valuable compendium for experienced researchers as well as for all newcomers to the field. Following a lengthy discussion of the origin of hemopoietic cells, regulatory elements for the differentiation of these cells and B and T cell lymphopoiesis, the book goes on to describe the generation of transgenic chickens as well as an additional basic feature in embryogenesis: the positioning of organ anlage, e.g. the limb bud. To round off, a valuable compilation of monoclonal antibodies further enhances the practical usefulness of this important book.
The chicken is a useful model for research into the basic features of immunology because its immune system functions in a way similar to that of human beings and because the chicken embryo is easily accessed experimentally. This book is a collection of comprehen sive articles updating chicken embryogenesis and immunology. It is now clear that it is possible to produce transgenic chickens by embryonic stem cell manipulation and transfer into the oocyte. Alternatively, the chick offers us the possibility of producing somatic chimeras by manipulating embryonic cells at the primitive streak or earlier stages. Working with later em bryos, we can learn the principles involved in the positioning of organ anlagen such as the limb bud. It is shown in this book that these structures are formed by appropriate cell and tissue arrangements driven by molecular factors. Work on the chicken has contributed substantially to our understanding of basic immunology, including the graft-vs. -host reaction, the clonal reactivity of immunocompetent cells, sepa ration of the T and B cell lineages, somatic diversification of the B cell repertoire by immunoglobulin (Ig) class switching, anti body diversification, Ig gene conversion, and the origin of the hematopoietic stem cell precursor of lymphoid and myeloid cells. Hematopoietic stem cells emerge successively from sev eral embryonic sites such as the yolk sac, the aorta, and the mesentery near the aorta."