Synopses & Reviews
Multiple drug resistance to antimicrobials is a growing problem that limits the effective lifetime of nearly all drugs developed against microorganisms. In Management of Multiple Drug-Resistant Infections, prominent clinicians and leading microbiologists describe how practicing physicians can best treat bacterial, viral, protozoal, and helminthic infections when there is significant resistance to antibiotics. The authors focus on the major hospital and community-acquired pathogens, including S. aureus, S. pneumoniae, Enterococcus, Acinetobacter, and M. tuberculosis, and on the management of such common problems as multiple drug-resistant urinary tract infections and gonorrhea. Among the resistant tropical organisms covered are Salmonella typhi, malaria, and Burkholderia pseudomalei. Resistance to such important antiviral classes as antiretrovirals and anticytomegaloviral agents is also discussed, as are those measures necessary to prevent the spread of infections among patients. When national or international treatment guidelines cannot be established, clinical trial data, in vitro susceptibility data, and epidemiologic and pharmacological evidence are cited to help make treatment decisions. Wherever possible, the question of drug resistance is set in the context of its biology and epidemiology. Comprehensive and practice-oriented, Management of Multiple Drug-Resistant Infections offers physicians and clinical microbiologists treating infectious disease patients not only a critically evaluated guide to the immense literature of the field, but also an up-to-date practical survey of today's gold-standard therapeutic strategies.
Review
Aus den Rezensionen: "Das von Stephen H. Gillespie herausgegebene Buch beschäftigt sich mit dem Umgang mit multi-resistenten Krankheitserregern. ... Es lässt sich zusammenfassen, dass die einzelnen Kapitel in unterschiedlichem Ausmaß die Epidemiologie, die Resistenzmechanismen, die klinische Bedeutung, Hygienemaßnahmen, die Schwierigkeiten bei der Testung und Empfehlungen zur Therapie vorstellen. Zum Teil wird auf Empfehlungen von Fachgesellschaften verwiesen, die Literaturangaben zu jedem Kapitel sind ausführlich und Tabellen durchweg übersichtlich. ... Insgesamt bietet das Buch sicher einen guten Überblick ..." (Friederike v. Loewenich, in: Mikrobiologe, 2006, Vol. 16, S. 48)
Review
"...highlights include excellent chapters on the management of multidrug-resistant malaria and drug-resistant infections caused by the human immunodeficiency virus...a book that will be an enjoyable and useful reference for physicians and microbiologists who are interested in developing a better grasp of this complex and rapidly changing field." -The New England Journal of Medicine "...excellent, concise discussions of treatment of resistant urinary tract infections, Salmonella infections, melioidosis, and malaria." - American College of Physicians
Synopsis
A comprehensive and cutting-edge review of how practicing physicians can best treat multiple drug resistance in bacterial, viral, protozoal, and helminthic infections. The authors focus on the major hospital and community-acquired pathogens, including S. aureus, S. pneumoniae, Enterococcus, Acinetobacter, and M. tuberculosis, and on the management of such common problems as multiple drug-resistant urinary tract infections and gonorrhea. Among the resistant tropical organisms covered are Salmonella typhi, malaria, and Burkholderia pseudomalei. Resistance to such important antiviral classes as antiretrovirals and anticytomegalovirals is also discussed, as are those measures necessary to prevent the spread of infections patients.
Table of Contents
Part I: Gram-Positive Bacteria
Management of Community-Acquired Pneumonia Caused by Drug-Resistant Streptococcus pneumoniae
Eric L. Nuermberger and William R. Bishai
Management of Meningitis Caused by Resistant Streptococcus pneumoniae
P. Fernández Viladrich
Emerging Resistance to Vancomycin, Rifampin, and Fluoroquinolones in Streptococcus pneumoniae
Joseph M. Blondeau
Management of Glycopeptide-Resistant Staphylococcus aureus Infections
A. Peter R. Wilson
Infections Caused by Glycopeptide-Resistant Gram-Positive Bacteria Excluding Staphylococci
Armine Sefton
Isolation Policies and the Hospital Management of Methicillin-Resistant Staphylococcus aureus: A Case of Evidence-Free Medicine?
Sheldon P. Stone
Part II: Gram-Negative Pathogens
The Management of Resistant Acinetobacter Infections in the Intensive Therapy Unit
Nicola Baker and Peter Hawkey
Drug-Resistant Helicobacter pylori
Peter J. Jenks
The Management of Antibiotic-Resistant Neisseria gonorrhoeae
Catherine A. Ison and Jonathan Ross
Management of Urinary Tract Infections Caused by Multiresistant Organisms
Jeremy M. T. Hamilton-Miller
Management of Multiple Drug-Resistant Salmonella Infections
Christopher M. Parry
Management of Melioidosis
Andrew J. H. Simpson
Part III: Mycobacteria
The Molecular Epidemiology of MDR-TB
Paul D. van Helden, Robin M. Warren, Pieter Uys, Gian D. van der Spuy, and Thomas C. Victor
The Management of Multiple Drug-Resistant Tuberculosis
Sanjay Bhagani and Marc Lipman
Management of Infection With Nontuberculosis Mycobacteria
Stephen H. Gillespie
Part IV: Fungal and Parasitic Infections
Management of Resistant Candida Infections
Sanya Clements and Christopher C. Kibbler
Management of Infection With Naturally Amphotericin B-Resistant Fungi
Thean Yen Tan and Rosemary A. Barnes
Management of Multiple Drug-Resistant Malaria
Elizabeth Ashley and François Nosten
Schistosome Drug Resistance: Praziquantel
Michael J. Doenhoff and Katherine Wheatcroft-Francklow
Part V. Viral Infections
Management of HIV Drug-Resistant Infections
Deenan Pillay
Multidrug Resistance in Human Cytomegalovirus
Vincent C. Emery, Mohammad Raza Naqvee, and Anuradha Chawla
Index