Synopses & Reviews
Matrix metalloproteinases (MMPs) are proteolytic enzymes that are involved in many physiological and pathological processes. The field of MMP research is very important due to the implications of the distinct paralogs in both human physiology and pathology. Over-activation of these enzymes results in tissue degradation, producing a wide array of disease processes such as rheumatoid arthritis, osteoarthritis, tumor growth and
Synopsis
MMPs are involved in numerous biological processes, fostering tissue degradation resulting in pathologies from osteoarthritis to tumor metastasis. This book focuses on the latest quantitative research into the endogenous inhibitors that disrupt MMP activity.
Table of Contents
Matrix Metalloproteinases.- Specificity of Binding with Matrix Metalloproteinases.- The Gelatinases and Their Inhibitors: The Structure-Activity Relationships.- Advances in Studies on Collagenase Inhibitors.- Hydroxamic Acids as Matrix Metalloproteinase Inhibitors.- Quantitative Structure-Activity Relationship Studies on Sulfonamide-Based MMP Inhibitors.- Matrix Metalloproteinase Inhibitors as Investigative Tools in the Pathogenesis and Management of Vascular Disease.